All Photos(1)
Synonym(s):
Human LL-37 amide Trifluoroacetate
Empirical Formula (Hill Notation):
C205H341N61O52 · xC2HF3O2
Molecular Weight:
4492.28 (free base basis)
UNSPSC Code:
51101500
NACRES:
NA.85
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
powder (Lyophilisate)
color
colorless to white
solubility
H2O: 1 mg/mL, clear, colorless
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
viruses
Mode of action
cell membrane | interferes
storage temp.
−20°C
Related Categories
Amino Acid Sequence
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-NH2
General description
Chemical structure: peptide
Application
LL-37 is used to study host defense mechanisms.
Biochem/physiol Actions
LL-37 is a muntifunctional host defense peptide with antibacterial, antiviral, and immunomodulating activities. It is the only cathelicidin-type peptide found in human. In addition to its antimicrobial activities, LL-37 has been found to regulate inflammation and neutralize lipopolysaccharides from Gram-negative bacteria.
Packaging
1mg
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Keep in a dry place.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
监管及禁止进口产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ainhoa Revilla-Guarinos et al.
Applied and environmental microbiology, 86(14) (2020-05-18)
Bce-like systems mediate resistance against antimicrobial peptides in Firmicutes bacteria. Lactobacillus casei BL23 encodes an "orphan" ABC transporter that, based on homology to BceAB-like systems, was proposed to contribute to antimicrobial peptide resistance. A mutant lacking the permease subunit was
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