90119
N-Methyl-L-valine
≥98% (TLC)
Synonym(s):
(S)-3-Methyl-2-(methylamino)butyric acid, N-Me-Val-OH
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About This Item
Empirical Formula (Hill Notation):
C6H13NO2
CAS Number:
Molecular Weight:
131.17
NACRES:
NA.32
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352202
MDL number:
Beilstein/REAXYS Number:
1721712
InChI key
AKCRVYNORCOYQT-YFKPBYRVSA-N
SMILES string
CN[C@@H](C(C)C)C(O)=O
InChI
1S/C6H13NO2/c1-4(2)5(7-3)6(8)9/h4-5,7H,1-3H3,(H,8,9)/t5-/m0/s1
assay
≥98% (TLC)
form
powder with small lumps
optical activity
[α]/D +25.0±1.0°, c = 1 in 1 M HCl
composition
carbon, 54.1-55.7% , nitrogen, 10.4-11.0%
technique(s)
ligand binding assay: suitable
color
white
Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Dam. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Franco Cataldo et al.
Life (Basel, Switzerland), 3(3), 449-473 (2013-01-01)
A series of non-proteinogenic amino acids, most of them found quite commonly in the meteorites known as carbonaceous chondrites, were subjected to solid state radiolysis in vacuum to a total radiation dose of 3.2 MGy corresponding to 23% of the
Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex.
David R Calabrese et al.
Nature communications, 9(1), 4229-4229 (2018-10-14)
G-quadruplexes (G4s) are noncanonical DNA structures that frequently occur in the promoter regions of oncogenes, such as MYC, and regulate gene expression. Although G4s are attractive therapeutic targets, ligands capable of discriminating between different G4 structures are rare. Here, we
D J Gordon et al.
Biochemistry, 40(28), 8237-8245 (2001-07-11)
A potential goal in the prevention or therapy of Alzheimer's disease is to decrease or eliminate neuritic plaques composed of fibrillar beta-amyloid (Abeta). In this paper we describe N-methyl amino acid containing congeners of the hydrophobic "core domain" of Abeta
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