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84655

Sigma-Aldrich

Schiff′s reagent for aldehydes

for microscopy

Synonym(s):

Fuchsin sulfurous acid

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About This Item

UNSPSC Code:
12352300
NACRES:
NA.21
grade:
for microscopy
form:
liquid

grade

for microscopy

Quality Level

100

form

liquid

application(s)

food and beverages

General description

Schiff′s reagent is used for the qualitative or quantitative assay of carbohydrates. Periodic acid-Schiff′s reagent (PAS) stain is broadly applicable in histology for visualizing glycogen, glycoproteins, mucins, and other polysaccharides in tissue and cells.

Application

Schiff′s reagent for aldehydes has been used:
  • in microtiter PAS assay to quantify the amount of secreted mucin in Vibrio cholera infected water
  • to stain the colonies of Clostridium perfringens in PGY agar plates to identify plasmalogen-deficient mutants
  • in periodic acid-Schiff′s reagent assay to quantify carbohydrates in a microtiter plate format

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H290,H350

Hazard Classifications

Carc. 1B - Met. Corr. 1

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6602
BCCJ8870
BCCJ8869
BCCH0780
BCCH0782

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Is Product 84655, Schiff’s reagent for aldehydes, suitable for staining tissue sections for PAS positive substances?

    Product 84655 is not suitability tested for the demonstration of aldehydes (PAS positive substances) in tissue sections. The formulation would suggest the product is intended for use in demonstrating aldehydes in solution - not in tissue sections. The recommended product for demonstrating PAS positive substances in tissue sections is 3952015. A kit is offered as product 395B-1KT.

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    Ask a Scientist here.

Michelle Kilcoyne et al.
Analytical biochemistry, 416(1), 18-26 (2011-05-31)
Microtiter plate colorimetric assays are widely used for analysis of carbohydrates and glycoconjugates. However, mucins are often not easily detected, as they have low neutral sugar content. We have adapted and optimised the periodic acid-Schiff's reagent (PAS) staining for microtiter
David R Jackson et al.
ACS chemical biology, 16(1), 6-13 (2020-12-23)
Plasmalogens are vinyl ether-containing lipids produced by mammals and bacteria. The aerobic biosynthetic pathway in eukaryotes and bacteria is known, but the anaerobic pathway has remained a mystery. Here, we describe a two-gene operon (plasmalogen synthase, pls) responsible for plasmalogen
Paul Breen et al.
Infection and immunity, 89(9), e0015721-e0015721 (2021-06-02)
Zebrafish (Danio rerio) is an attractive model organism to use for an array of scientific studies, including host-microbe interactions. Zebrafish contain a core (i.e., consistently detected) intestinal microbiome consisting primarily of Proteobacteria. Furthermore, this core intestinal microbiome is plastic and
Paul Breen et al.
Infection and immunity, 89(9), e0015121-e0015121 (2021-06-08)
Zebrafish (Danio rerio) are an attractive model organism for a variety of scientific studies, including host-microbe interactions. The organism is particularly useful for the study of aquatic microbes that can colonize vertebrate hosts, including Vibrio cholerae, an intestinal pathogen. V.
Yixiang Zhong et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21379-e21379 (2021-02-11)
Traditionally cultured monolayers of primary human hepatocytes (PHHs) deteriorate within days and thereby become unsuitable for drug-related studies. PHH spheroids (3D PHHs) maintain liver functions for weeks, but are considerably more demanding. Recently, a chemical-based approach (5C PHHs) succeeded in

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