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82435

Sigma-Aldrich

Puerarin

≥98.0% (HPLC)

Synonym(s):

8-(β-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one, Kakonein

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About This Item

Empirical Formula (Hill Notation):
C21H20O9
CAS Number:
3681-99-0
Molecular Weight:
416.38
Beilstein:
64198
MDL number:
MFCD00076007
UNSPSC Code:
12352200
PubChem Substance ID:
57652917
NACRES:
NA.77

Quality Level

100

Assay

≥98.0% (HPLC)

form

powder

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)ccc3C(=O)C(=COc23)c4ccc(O)cc4

InChI

1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

InChI key

HKEAFJYKMMKDOR-VPRICQMDSA-N

Gene Information

mouse ... Aldh1a2(19378) , Maoa(17161)

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Biochem/physiol Actions

Isoflavone component of kudzu. Reduces anxiety symptoms associated with alcohol withdrawal.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK6262
BCCJ0445
BCBZ8152
BCBR8847V
BCBP6288V

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David H Overstreet et al.
Pharmacology, biochemistry, and behavior, 75(3), 619-625 (2003-08-05)
Because extracts of kudzu have been used as a hangover remedy in China for many centuries, we tested the ability of NPI-031G (puerarin), an isoflavone isolated from kudzu, to counteract anxiogenic effects associated with withdrawal from chronic alcohol exposure. NPI-O31G
Wen Cheng et al.
PloS one, 7(9), e45529-e45529 (2012-10-03)
Puerarin is a major isoflavonoid compound extracted from Radix puerariae. It has a weak estrogenic action by binding to estrogen receptors (ERs). In our early clinical practice to treat endometriosis, a better therapeutic effect was achieved if the formula of
Xin-Yi Liu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(22), 3391-3394 (2013-02-05)
To detect the stability of PEGylated puerarin (PEG-PUE), in order to provide experimental basis for storage conditions of PEGylated puerarin. First, a method for determining the content of PEG-PUE was established. Next, a system study was conducted for the stability
Jing-Hua Peng et al.
The Journal of pharmacology and experimental therapeutics, 344(3), 646-654 (2013-01-02)
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotoxin gut leakage, the subsequent Kupffer cell activation, and endotoxin receptors
Benguo Liu et al.
Journal of agricultural and food chemistry, 60(51), 12501-12507 (2012-12-12)
Puerarin is a natural isoflavone, found in the Chinese medicinal plant Ge-gen, with many reported health-promoting properties. However, its low water solubility impedes its application in pharmaceutical and functional food products. This study explores the formation of inclusion complex between
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