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77140

Sigma-Aldrich

Peptidoglycan from Staphylococcus aureus

cell wall component

Synonym(s):

Peptidoglycan from S. aureus

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About This Item

MDL number:
MFCD00212486
UNSPSC Code:
12352201
NACRES:
NA.32

Quality Level

100

form

lyophilized powder

solubility

soluble, hazy to turbid, colorless to faintly yellow

storage temp.

−20°C

Related Categories

Application

Peptidoglycan from Staphylococcus aureus has been used:
  • for the stimulation of lymphocytes: peptidoglycan activates the toll-like receptor 2 (TLR2), present in mammalian cells. It works as an antagonist of Poly (I:C)
  • for g-type lysozyme stimulation by intraperitoneally inoculating it into sole specimens
  • in phosphate buffer saline and injected into Labeo rohita fingerlings, to study its effect on nucleotide-binding oligomerization domain-2 (NOD-2) gene expression

Biochem/physiol Actions

The cell wall of gram positive bacteria is largely made up of peptidoglycan. It is composed of polysaccharide chains interlinked by peptide bridges. This peptidoglycan gives a certain rigidity to the cell wall and gives the cell mechanical strength. It is a surface molecule which is known to stimulate immune reactions including cytokine production to fever.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Major component of the cell wall in gram positive organisms. Consists of a glycan backbone with alternating β 1-4 linked residues of N-acetyl-D-glucosamine and muramic acid. The immunological activities of bacterial peptidoglycans; Peptidoglycan types of bacterial cell walls and their taxonomic implications; Antibody response to peptidoglycan during staphylococcal infections

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCJ7175
BCCF2500
BCCC1420
BCBZ7206
BCBW7713

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Can Product 77140, Peptidoglycan, be solubilized in water?

    No, the product is not soluble in water, or in other solvents for that matter. It forms a suspension in water.  

  6. Does Product 77140, Peptidoglycan, have a recommended retest date?

    If a product has a recommended retest date this would be on the Certificate of Analysis found at our website. If no recommended retest date is found on the Certificate of Analysis, then the guarantee of quality is one year from the time of delivery for unopened bottles stored at the recommended temperature.

  7. How can solutions of Product 77140, Peptidoglycan, be stored?

    Sigma has not evaluated the solution stability of solutions.  It is therefore recommended that fresh solutions be prepared.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

L J Wheat et al.
The Journal of infectious diseases, 147(1), 16-22 (1983-01-01)
Levels of antibodies to peptidoglycan were measured by solid-phase radioimmunoassay in 76 patients with Staphylococcus aureus infections and 44 patients with infections caused by other bacteria. Levels of IgM antibodies to peptidoglycan were elevated in 24% of the patients with
Xue Kong et al.
Frontiers in physiology, 9, 1476-1476 (2018-11-09)
Vesicomyidae clams are common species living in cold seeps, which incorporates symbiotic bacteria into their body maintaining endosymbiosis relationship. As members of pattern recognition receptor (PRR) family, peptidoglycan recognition proteins (PGRPs) recognize pathogen associated molecular patterns and play an important
Genomic characterization, phylogeny and gene regulation of g-type lysozyme in sole (Solea senegalensis)
Ponce M, et al.
Fish & Shellfish Immunology, 31(6), 925-937 (2011)
The immunological activities of bacterial peptidoglycans.
D E Stewart-Tull
Annual review of microbiology, 34, 311-340 (1980-01-01)
Peptidoglycan types of bacterial cell walls and their taxonomic implications.
K H Schleifer et al.
Bacteriological reviews, 36(4), 407-477 (1972-12-01)
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Articles

Peptidoglycan Structure and Biosynthesis

Peptidoglycan structure: alternating GlcNAc and N-acetylmuramic acid cross-linked to peptides form the basic backbone.

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