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Safety Information

73248

Sigma-Aldrich

Melengestrol acetate

≥97.0% (HPLC)

Synonym(s):

17α-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione, MGA

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About This Item

Empirical Formula (Hill Notation):
C25H32O4
CAS Number:
2919-66-6
Molecular Weight:
396.52
Beilstein:
2066919
EC Number:
220-859-7
MDL number:
MFCD00072142
UNSPSC Code:
12352200
PubChem Substance ID:
57652468

Assay

≥97.0% (HPLC)

form

solid

mp

202-204 °C (lit.)

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC(=C)[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

InChI

1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1

InChI key

UDKABVSQKJNZBH-DWNQPYOZSA-N

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Biochem/physiol Actions

Causes shrinkage of androgen-dependent prostate tumors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCBK4201V
455906/1
442511/1
414577/1
1170011

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G M Padilla et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 68(10), 1181-1188 (1990-10-01)
We had previously reported that 6-methylene progesterone, an inhibitor of 5 alpha-reductase, the enzyme which converts testosterone to dihydrotestosterone, markedly inhibited growth of the androgen-dependent Dunning R3327-H rat prostatic tumors. We now find that the progesterone derivatives melengestrol acetate (MGA)
Sarah Kelly Mortensen et al.
Analytica chimica acta, 586(1-2), 217-222 (2007-03-28)
A confirmatory method has been developed and validated for the determination of chlormadinone acetate (CMA), megestrol acetate (MGA), melengestrol acetate (MLA) and medroxyprogesterone acetate (MPA) in bovine and porcine plasma. Analytes are extracted from plasma samples using matrix-assisted liquid-liquid extraction
M E Corrigan et al.
Journal of animal science, 85(7), 1770-1779 (2007-03-21)
Previous research from our laboratory has indicated that melengestrol acetate (MGA) added to the diet during the first 35 d after arrival in the feedlot improves growth rates and tends to reduce chronic respiratory disease in heifers naturally challenged with
D A Mallory et al.
Journal of animal science, 88(11), 3568-3578 (2010-07-27)
Two experiments evaluated long-term progestin-based estrus-synchronization programs on the basis of potential for use in facilitating fixed-time AI in estrous cycling and prepubertal beef heifers. In Exp. 1, heifers were assigned to 1 of 2 treatments by age, BW, and
S A Tauck et al.
Theriogenology, 68(2), 162-167 (2007-06-05)
The objectives of this experiment were to compare estrous synchronization responses and AI pregnancy rates of beef heifers using protocols that included either CIDR or MGA as the progestin source. The hypotheses tested were that: (1) estrous synchronization responses after
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