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Merck
CN

73248

Melengestrol acetate

≥97.0% (HPLC)

Synonym(s):

17α-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione, MGA

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About This Item

Empirical Formula (Hill Notation):
C25H32O4
CAS Number:
2919-66-6
Molecular Weight:
396.52
PubChem Substance ID:
57652468
EC Number:
220-859-7
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
2066919
MDL number:
MFCD00072142

Key Documents

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InChI key

UDKABVSQKJNZBH-DWNQPYOZSA-N

InChI

1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC(=C)[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

assay

≥97.0% (HPLC)

form

solid

mp

202-204 °C (lit.)

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Biochem/physiol Actions

Causes shrinkage of androgen-dependent prostate tumors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361fd

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCBK4201V
455906/1
442511/1
414577/1
1170011

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Brett J Theeler et al.
Journal of the neurological sciences, 353(1-2), 92-97 (2015-05-03)
Brainstem gliomas are rare in adults and overall have superior survival outcomes compared to pediatric brainstem gliomas. We conducted a retrospective data and tissue analysis of all adult patients (≥ 18 years old) with World Health Organization (WHO) Grade II
G M Padilla et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 68(10), 1181-1188 (1990-10-01)
We had previously reported that 6-methylene progesterone, an inhibitor of 5 alpha-reductase, the enzyme which converts testosterone to dihydrotestosterone, markedly inhibited growth of the androgen-dependent Dunning R3327-H rat prostatic tumors. We now find that the progesterone derivatives melengestrol acetate (MGA)
G A Perry et al.
Theriogenology, 71(5), 775-779 (2008-11-14)
Treatment with GnRH at the onset of standing estrus increased pregnancy percentages and circulating concentrations of progesterone in repeat breeder dairy cows. The objective of this study was to determine the effect of treatment with GnRH at AI on concentrations
D R Eborn et al.
Journal of animal science, 91(2), 666-672 (2012-12-12)
Two experiments were conducted over 3 yr to determine pregnancy rates in beef heifers after a timed AI in response to the 7-11 Synch protocol. In Exp. 1, 179 heifers were either fed melengestrol acetate (MGA; 7-11 Synch) or given
D McAloose et al.
Veterinary pathology, 44(3), 320-326 (2007-05-11)
Melengestrol acetate (MGA), a potent synthetic progestin, has been used as a contraceptive in zoo felids since 1975. Mammary gland carcinomas have been linked to MGA treatment in zoo felids, but the histologic features of these tumors and steroid receptor
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