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Safety Information

73248

Sigma-Aldrich

Melengestrol acetate

≥97.0% (HPLC)

Synonym(s):

17α-Acetoxy-6-methyl-16-methylene-4,6-pregnadiene-3,20-dione, MGA

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About This Item

Empirical Formula (Hill Notation):
C25H32O4
CAS Number:
2919-66-6
Molecular Weight:
396.52
Beilstein:
2066919
EC Number:
220-859-7
MDL number:
MFCD00072142
UNSPSC Code:
12352200
PubChem Substance ID:
57652468

Assay

≥97.0% (HPLC)

form

solid

mp

202-204 °C (lit.)

SMILES string

[H][C@]12CC[C@@]3(C)[C@@]([H])(CC(=C)[C@]3(OC(C)=O)C(C)=O)[C@]1([H])C=C(C)C4=CC(=O)CC[C@]24C

InChI

1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1

InChI key

UDKABVSQKJNZBH-DWNQPYOZSA-N

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Biochem/physiol Actions

Causes shrinkage of androgen-dependent prostate tumors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361fd

Hazard Classifications

Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCBK4201V
455906/1
442511/1
414577/1
1170011

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Brett J Theeler et al.
Journal of the neurological sciences, 353(1-2), 92-97 (2015-05-03)
Brainstem gliomas are rare in adults and overall have superior survival outcomes compared to pediatric brainstem gliomas. We conducted a retrospective data and tissue analysis of all adult patients (≥ 18 years old) with World Health Organization (WHO) Grade II
G M Padilla et al.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 68(10), 1181-1188 (1990-10-01)
We had previously reported that 6-methylene progesterone, an inhibitor of 5 alpha-reductase, the enzyme which converts testosterone to dihydrotestosterone, markedly inhibited growth of the androgen-dependent Dunning R3327-H rat prostatic tumors. We now find that the progesterone derivatives melengestrol acetate (MGA)
D McAloose et al.
Veterinary pathology, 44(3), 320-326 (2007-05-11)
Melengestrol acetate (MGA), a potent synthetic progestin, has been used as a contraceptive in zoo felids since 1975. Mammary gland carcinomas have been linked to MGA treatment in zoo felids, but the histologic features of these tumors and steroid receptor
Madis Lõhmus et al.
Analytica chimica acta, 586(1-2), 233-238 (2007-03-28)
The use of gestagens in animal fattening is prohibited within the European Union. Recently, the use of spectrometric methods for the detection and confirmation of banned substances was made obligatory. Therefore, conventional high-performance liquid chromatographic (HPLC) methods have been superseded.
D R Eborn et al.
Journal of animal science, 91(2), 666-672 (2012-12-12)
Two experiments were conducted over 3 yr to determine pregnancy rates in beef heifers after a timed AI in response to the 7-11 Synch protocol. In Exp. 1, 179 heifers were either fed melengestrol acetate (MGA; 7-11 Synch) or given
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