72831
Ketoreductase
recombinant, expressed in E. coli, ≥2.2 U/mg
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About This Item
recombinant
expressed in E. coli
form
powder
powder with small lumps
specific activity
≥2.2 U/mg
storage temp.
2-8°C
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Application
Ketoreductases are used to study the stereospecificity of ketoreductase domains . They may be used to reduce precursors of α-chloroalcohols, which are synthetic intermediates for various pharmaceutical compounds . Product 72831 is recombinant and expressed in E. coli at ≥ 2.2 U/mg.
Biochem/physiol Actions
Ketoreductase, Product 77857, reduces 4-chloroacetoacetate with NADPH as a cosubstrate.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Unit Definition
1 U corresponds to the amount of enzyme which reduces 1 μmol 4-chloroacetoacetate per minute at pH 6.0 and 25°C (cosubstrate NADPH).
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Automation Highlights from the Literature
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Jonathan A Doorn et al.
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X Li et al.
Wei sheng wu xue bao = Acta microbiologica Sinica, 41(4), 463-468 (2003-01-30)
ANADPH-dependent 2-Oxoaldehyde reductase was isolated and purified from a marine bacteria Bacillus sp. The purification procedure involved ammonium sulfate fractionation and Q Sepharose FF, Hydroxyapatite, Sephadex G-100 column chromatographies. The specific activity of the purified enzyme was increased by 141.1
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