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71859

Sigma-Aldrich

Sodium (meta)periodate

BioUltra, ≥99.5% (RT)

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Synonym(s):
Sodium periodate
Linear Formula:
NaIO4
CAS Number:
7790-28-5
Molecular Weight:
213.89
EC Number:
232-197-6
MDL number:
MFCD00003534
UNSPSC Code:
12352201
PubChem Substance ID:
57652368
NACRES:
NA.25

product line

BioUltra

Quality Level

200

Assay

≥99.5% (RT)

form

crystals

impurities

insoluble matter, passes filter test

loss

≤0.1% loss on drying, 20 °C (HV)

color

white to light yellow

pH

3.5-5.5 (25 °C, 0.5 M in H2O)

mp

270  °C ((518 °F ) at 1,013 hPa - OECD Test Guideline 102 -)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

anion traces

bromide, bromate, chloride, chlorate (as Cl-): ≤100 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

absorption

cut-off at 350 nm in H2O at 0.05 M

SMILES string

[Na+].[O-]I(=O)(=O)=O

InChI

1S/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1

InChI key

JQWHASGSAFIOCM-UHFFFAOYSA-M

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Application

Sodium periodate is use in molecular biology and carbohydrate research to cleave carbon-carbon bonds of carbohydrates alginates, chitosans, hyaluronan, scleroglucan/schizophyllan, cellulose nucleic acids other molecules rich in hydroxyls and ketones to prepare them for chemical and physical modifications.
Useful reagent for the oxidation of carbohydrates prior to labeling with biotin hydrazide

Other Notes

Periodate oxidation of agarose gels in enzyme immobilization; Preparation of oligonucleotide 3′-dialcohols in ribonucleoside labeling; Cleavage of cross-linked proteins.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1C - STOT RE 1

Target Organs

thymus gland

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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U Bergmann et al.
Biochemistry, 32(11), 2880-2887 (1993-03-23)
50S ribosomal subunits from the extreme halophilic archaebacterium Haloarcula marismortui were treated with the homobifunctional protein-protein cross-linking reagents diepoxybutane (4 A) and dithiobis(succinimidyl propionate) (12 A). The dominant product with both cross-linking reagents was identified on the protein level as
3H and 32P derivative methods for base composition and sequence analysis of RNA.
K Randerath et al.
Methods in enzymology, 65(1), 638-680 (1980-01-01)
Immobilization of enzymes to agar, agarose, and Sephadex supports.
J Porath et al.
Methods in enzymology, 44, 19-45 (1976-01-01)
Ya-Pu Li et al.
Nature communications, 10(1), 1368-1368 (2019-03-27)
Long noncoding RNAs (lncRNAs) have emerged as important components of gene regulatory network in embryonic stem cells (ESCs). However, the function and molecular mechanism of lncRNAs are still largely unknown. Here we identifies Trincr1 (TRIM71 interacting long noncoding RNA 1)
Quyen Cheng et al.
PloS one, 10(5), e0124117-e0124117 (2015-05-06)
Neutrophil recruitment (NR) to sites of sterile inflammation plays a key role in tissue damage and healing potential of lesions characteristic to non-infectious inflammatory diseases. Previous studies suggested significant genetic control of neutrophil survival, function, and migration in inflammatory responses
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