Skip to Content
Merck
CN

70215

2,3-Naphthalenedicarboxaldehyde

suitable for fluorescence

Synonym(s):

NDA

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Linear Formula:
C10H6(CHO)2
CAS Number:
7149-49-7
Molecular Weight:
184.19
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
329762349
MDL number:
MFCD00016618
Beilstein/REAXYS Number:
2207267

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

2,3-Naphthalenedicarboxaldehyde, suitable for fluorescence

InChI key

ZIPLKLQPLOWLTM-UHFFFAOYSA-N

SMILES string

[H]C(=O)c1cc2ccccc2cc1C([H])=O

InChI

1S/C12H8O2/c13-7-11-5-9-3-1-2-4-10(9)6-12(11)8-14/h1-8H

form

crystals

impurities

≤2% mono- and dicarboxylic acid (1H-NMR)

mp

131-133 °C (lit.)
132-135 °C

fluorescence

λex 420 nm; λem ~480 nm in 0.1 M borate pH 9.3 (after derivatization with glycine [~90 μM glycine, ~20 μM N-])

suitability

suitable for fluorescence

storage temp.

2-8°C

Quality Level

100

Looking for similar products? Visit Product Comparison Guide

Application

2,3-Naphthalenedicarboxaldehyde is used as a fluorescent labelling agent for quantification of Histamine in human immunoglobulin preparations. NAD is used as a derivatization agent for glutathione to quantify protein glutathionylation. It is a suitable reagent used for the development of fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.

Features and Benefits

NDA based fluorescent assays have the following benefits over O-Phthalaldehyde (OPA):

  • High Reaction rate.
  • High Fluorescence quantum yield.
  • No uncommon excitation wavelength.
  • No side reactions.

General description

2,3-Naphthalenedicarboxaldehyde, also known as NDA, is a novel fluorescent derivatization agent. The fluorescence max. excitation of NDA is in the range of 424 nm and max. emission is achieved at 484nm.

2,3-Naphthalenedicarboxaldehyde is a fluorescent derivatization agent of primary amines, amino acids, and small peptides. The reaction between the amino compounds and NDA results in highly fluorescent and stable derivative compounds.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCN9164
BCBN9885V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jung-Hwan Kim et al.
Osong public health and research perspectives, 2(2), 127-134 (2011-09-01)
To develop and optimize quantitative HPLC method using 2,3-naphthalenedicarboxaldehyde (NDA) after simple and efficient solid phase extraction to determine the histamine in a biopharmaceutical (Histobulin™). The HPLC method was established using NDA-induced Histobulin and compared with the recently reported HPLC
S.M. Lunte et al.
LC-GC, 7, 908-908 (1989)
Yu Hui et al.
Electrophoresis, 33(12), 1911-1920 (2012-06-29)
Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase and a risk factor for cardiovascular events. We have developed a new derivatization method to enable baseline separation of the regio-isomers, ADMA, and symmetric dimethylarginine (SDMA), within 15 min on
An improved mechanism-based cross-linker for multiplexed kinase detection and inhibition in a complex proteome.
Kai Liu et al.
Chembiochem : a European journal of chemical biology, 9(12), 1883-1888 (2008-07-16)
P. de Montigny et al.
Analytical Chemistry, 59, 1096-1096 (1987)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service