58756
1-(5-Isoquinolinesulfonyl)-3-methylpiperazine
≥98.0% (HPLC)
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Synonym(s):
1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7
Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
Molecular Weight:
291.37
Beilstein:
5445506
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98.0% (HPLC)
form
powder
storage temp.
2-8°C
SMILES string
CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23
InChI
1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
InChI key
QGSCXAWTTISKLF-UHFFFAOYSA-N
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Biochem/physiol Actions
Less potent inhibitor of protein kinaseC than H-7
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J Duraj et al.
Neoplasma, 44(4), 205-211 (1997-01-01)
The human pre-B acute lymphoblastic leukemia cell line REH6 was utilized for characterization of CD45 glycoprotein by monoclonal antibodies (mAb) recognizing four distinct CD45 antigen specificities, i.e. nonrestricted CD45, restricted CD45RA, CD45RB and CD45R0. Immunoprecipitation revealed two antigen specificities on
A Broberg et al.
Biochemical and biophysical research communications, 280(1), 328-333 (2001-02-13)
Integrin alpha1beta1, one of the cellular collagen receptors, can participate in the regulation of collagen accumulation by acting as a negative feedback regulator. The molecular mechanism behind this phenomenon has been unknown. We have plated cells inside three-dimensional collagen and
C A Gebert et al.
Molecular endocrinology (Baltimore, Md.), 13(1), 38-56 (1999-01-19)
STAT5b (signal transducer and activator of transcription 5b) is a key mediator of the effects of plasma GH pulses on male-specific liver gene expression. STAT5b is activated in liver cells in vivo by physiological pulses of GH and then is
C D Balaban et al.
Brain research, 845(1), 97-101 (1999-10-26)
This study tests the hypothesis that activation of protein kinase C (PKC) is a critical step for early recovery from spontaneous nystagmus after unilateral ablation of the vestibular periphery. Halothane-NO(2)-O(2)-anesthetized Long-Evans rats received a 5-microl intracerebroventricular bolus of vehicle (distilled
B L Sailer et al.
Cytometry, 31(3), 208-216 (1998-03-27)
Fluorescence lifetime analysis was used in combination with conventional flow cytometric analysis to monitor changes in residual chromatin in apoptotic HL-60 cell populations following treatment with camptothecin, cycloheximide, genistein, H7, and gamma radiation. Data presented show that all of these
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