58756
1-(5-Isoquinolinesulfonyl)-3-methylpiperazine
≥98.0% (HPLC)
Synonym(s):
1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7
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About This Item
Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
Molecular Weight:
291.37
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5445506
InChI
1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
SMILES string
CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23
InChI key
QGSCXAWTTISKLF-UHFFFAOYSA-N
assay
≥98.0% (HPLC)
form
powder
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Less potent inhibitor of protein kinaseC than H-7
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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C A Gebert et al.
Molecular endocrinology (Baltimore, Md.), 13(1), 38-56 (1999-01-19)
STAT5b (signal transducer and activator of transcription 5b) is a key mediator of the effects of plasma GH pulses on male-specific liver gene expression. STAT5b is activated in liver cells in vivo by physiological pulses of GH and then is
A Broberg et al.
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Integrin alpha1beta1, one of the cellular collagen receptors, can participate in the regulation of collagen accumulation by acting as a negative feedback regulator. The molecular mechanism behind this phenomenon has been unknown. We have plated cells inside three-dimensional collagen and
L B Quesnel et al.
The Journal of antimicrobial chemotherapy, 41(2), 215-221 (1998-04-09)
Cystic fibrosis (CF) results from mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) which is a regulated chloride channel. The deltaF508 mutation prevents the post-translational glycosylation and membrane insertion of the protein. Severe disease follows, with the
B L Sailer et al.
Cytometry, 31(3), 208-216 (1998-03-27)
Fluorescence lifetime analysis was used in combination with conventional flow cytometric analysis to monitor changes in residual chromatin in apoptotic HL-60 cell populations following treatment with camptothecin, cycloheximide, genistein, H7, and gamma radiation. Data presented show that all of these
H Takahashi et al.
Biological & pharmaceutical bulletin, 20(4), 446-448 (1997-04-01)
Capric acid (C10) enhanced the absorption of cefoxitin sodium in a concentration-dependent manner following the rectal administration as a suppository in rats. The optimal concentration of C10 was 13%. C10 administered as a suppository also reduced rectal membrane resistance (Rm)
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