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3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester

Name: 3-(4-Hydroxyphenyl)propionic acid <I>N</I>-hydroxysuccinimide ester
Brand: SIGMA

≥97.0% (C), BioReagent

Synonym(s):

N-Succinimidyl 3-(4-hydroxyphenyl)propionate, N-[(4-Hydroxyhydrocinnamoyl)oxy]succinimide, Bolton-Hunter reagent precursor, Rudinger reagent, SHPP

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₃NO₅

CAS Number:

34071-95-9

Molecular Weight:

263.25

Beilstein:

1545011

EC Number:

251-818-1

MDL number:

MFCD00005515

UNSPSC Code:

12352106

PubChem Substance ID:

57651567

NACRES:

NA.25

product name

3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester, BioReagent, suitable for fluorescence, ≥97.0% (C)

product line

BioReagent

Quality Level

200

Assay

≥97.0% (C)

mp

132-133 °C (lit.)

fluorescence

λ_ex 320 nm; λ_em 409 nm in 0.1 M Tris pH 8.8, 2 mM H₂O₂, peroxidase

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

Oc1ccc(CCC(=O)ON2C(=O)CCC2=O)cc1

InChI

1S/C13H13NO5/c15-10-4-1-9(2-5-10)3-8-13(18)19-14-11(16)6-7-12(14)17/h1-2,4-5,15H,3,6-8H2

InChI key

KYRUKRFVOACELK-UHFFFAOYSA-N

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Application

Bolton-Hunter reagent precursor (3-(4-Hydroxyphenyl)propionic acid N-hydroxysuccinimide ester) is a hydroxysuccinimide ester used as an intermediate for high radioactive radioiodination of proteins.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Appendix: Preparation of N-succinimidyl 3-(4-hydroxyphenyl)propionate.

J Rudinger et al.

The Biochemical journal, 133(3), 538-539 (1973-07-01)

A comparison of two procedures for labelling the surface of the hydatid disease organism, Echinococcus granulosus, with 125I.

D P McManus et al.

Journal of helminthology, 61(1), 47-52 (1987-03-01)

Living, intact protoscoleces of the British horse and sheep strains of Echinococcus granulosus were subjected to surface radioiodination procedures using 125I and Iodogen and 125I-Bolton Hunter reagent. Subsequent combined electron microscopy and autoradiography revealed specific surface membrane labelling with the

Radioiodination and biodistribution of quantum dots using Bolton-Hunter reagent.

Jae Jun Park et al.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 69(1), 56-62 (2010-10-05)

In this study, the radioiodination and biodistribution of quantum dots (QDs) using Bolton-Hunter reagent were investigated. Radioiodination yield was 33.4 ± 2.0%. Fluorescent intensity of radioiodinated QDs decreased to 75.4% of the maximum prior to radioiodination. In biodistribution and ex

Radioiodination of cellular proteins.

Caplan S, Baniyash M.

Current Protocols in Cell Biology, 7, 7-7 (2001)

Labeling of peptides and proteins by radioiodination.

Bailey GS.

Methods Mol. Cell Biol., 32, 441-448 (1994)

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