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Merck
CN

53467

2,3-Dioleyloxy-1-(dimethylamino)propane

≥98.0% (TLC)

Synonym(s):

1,2-Dioleyloxy-3-(dimethylamino)propane, N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine, DODMA

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About This Item

Empirical Formula (Hill Notation):
C41H81NO2
CAS Number:
104162-47-2
Molecular Weight:
620.09
UNSPSC Code:
12352211
NACRES:
NA.85
PubChem Substance ID:
329757947
MDL number:
MFCD22200991
Beilstein/REAXYS Number:
10139013

Key Documents

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Product Name

2,3-Dioleyloxy-1-(dimethylamino)propane, ≥98.0% (TLC)

form

liquid

InChI key

GLGLUQVVDHRLQK-WRBBJXAJSA-N

SMILES string

CCCCCCCC\C=C/CCCCCCCCOCC(CN(C)C)OCCCCCCCC\C=C/CCCCCCCC

InChI

1S/C41H81NO2/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-43-40-41(39-42(3)4)44-38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,41H,5-18,23-40H2,1-4H3/b21-19-,22-20-

biological source

synthetic

assay

≥98.0% (TLC)

functional group

amine
ether

lipid type

cationic lipids

storage temp.

−20°C

Quality Level

100

Related Categories

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM9485
BCCL3328
BCCJ7359
BCCK4521
BCCJ1206

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Lloyd B Jeffs et al.
Pharmaceutical research, 22(3), 362-372 (2005-04-20)
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution
Yujing Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 13(2), 371-381 (2016-10-18)
Microfluidic systems can accelerate clinical translation of nanoparticles due to their ability to generate nanoparticles in a well-controlled and reproducible manner. In this study, a single-step process based on microfluidic focusing (MF) was employed to synthesize transferrin-conjugated lipid nanoparticles (Tf-LNPs)
Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids.
Heyes, J., et al.
J. Controlled Release, 107, 276-287 (2005)
Adam Judge et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 13(2), 328-337 (2005-11-09)
The systemic application of nucleic acid drugs requires delivery systems that overcome the poor pharmacokinetics, limited biodistribution, and inefficient uptake of nucleic acids. PEGylated liposomes show considerable promise because of their intrinsic ability to accumulate at disease sites and facilitate
Brett A Duguay et al.
Journal of leukocyte biology, 104(3), 587-596 (2018-04-19)
Mast cells are important immune cells that have significant roles in mediating allergy and asthma. Therefore, studying the molecular mechanisms regulating these and other processes in mast cells is important to elucidate. Methods such as lipofection, transduction, and electroporation are
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