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51947

Sigma-Aldrich

N-Acetyl-D-galactosamine 6-sulfate sodium salt

≥98.0% (TLC)

Synonym(s):

GalNAc-6S

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About This Item

Linear Formula:
C8H14O9NSNa
CAS Number:
204575-07-5
Molecular Weight:
323.25
MDL number:
MFCD00214239
UNSPSC Code:
12352201
PubChem Substance ID:
329757768

biological source

bovine (Ruminant- Cow, Ox, Buffalo)

Quality Level

100

description

Mixed anomers

Assay

≥98.0% (TLC)

form

solid

optical activity

[α]/D 54.0±4.0, c = 0.1% (w/v) in water

technique(s)

thin layer chromatography (TLC): suitable

storage temp.

−20°C

SMILES string

[Na+].CC(=O)N[C@H]1C(O)O[C@H](COS([O-])(=O)=O)[C@H](O)[C@@H]1O

InChI

1S/C8H15NO9S.Na/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16;/h4-8,11-13H,2H2,1H3,(H,9,10)(H,14,15,16);/q;+1/p-1/t4-,5-,6+,7-,8?;/m1./s1

InChI key

CBUJZKTVEFVBBG-DBKUKYHUSA-M

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Application

N-Acetyl-D-galactosamine 6-sulfate (GalNAc-6S) is used as a substrate to identify, differentiate and characterize N-acetylgalactosamine sulfatase(s). GalNAc-6S is used to study the rare autosomal recessive disorder Mucopolysaccharidosis IVA (MPS IVA).

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBN4984V
BCBK3020V
BCBK9592V
1443260
1432003

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S Tomatsu et al.
Current pharmaceutical biotechnology, 12(6), 931-945 (2011-04-22)
Mucopolysaccharidosis IVA (MPS IVA), also known as Morquio A, is a rare, autosomal recessive disorder caused by a deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate-sulfatase (GALNS), which catalyzes a step in the catabolism of glycosaminoglycans (GAGs), keratan sulfate (KS) and chondroitin-6-sulfate
Václav Profant et al.
Physical chemistry chemical physics : PCCP, 21(14), 7367-7377 (2019-03-23)
Glycosaminoglycans are linear carbohydrate polymers with essential roles in many biological processes. Chondroitin sulfate (CS) is one of them, omnipresent in living organisms as an important structural component of cartilage. It provides much of its resistance to compression. Despite its
Souhir Khedhiri et al.
Diagnostic pathology, 6, 11-11 (2011-01-22)
Mucopolysaccharidosis type IVA or Morquio A syndrome is characterized by the lack of N-acetylgalactosamine-6-sulfate-sulfatase and the accumulation of keratan sulfate and chondroitin-6-sulfate in the lysosomes. At least, 148 mutations and 16 polymorphisms were identified in the GALNS gene.The aim of
M Masue et al.
Journal of biochemistry, 110(6), 965-970 (1991-12-01)
N-Acetylgalactosamine-6-sulfate sulfatase from human placenta was purified 33,600-fold using beta-N-acetyl-D-galactosamine 6-sulfate-(1----4)-beta-D-glucuronic acid-(1----3)-N-acetyl-D-[3H]galactosaminitol 6-sulfate as the substrate. This enzyme is an oligomer with a molecular mass of 120 kDa and consists of polypeptides of 40 and 15 kDa. The 15 kDa
J Bielicki et al.
The Biochemical journal, 279 ( Pt 2), 515-520 (1991-10-15)
Human N-acetylgalactosamine 6-sulphatase (EC 3.1.6.14), which is involved in the lysosomal degradation of the glycosaminoglycans keratan sulphate and chondroitin 6-sulphate, was purified more than 130,000-fold in 2.8% yield from liver by an eight-step column procedure. One major form was identified
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