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5133

Sigma-Aldrich

Bovine Collagen Type I & III

from bovine hide, liquid, 10 mg/mL, suitable for cell culture, used for 3D hydrogel formation, FlexiCol®

Synonym(s):

Sepharose 4B

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.75

product name

FibriCol®, Collagen solution from Bovine hide, 97% Type I with the remainder of Type III collagen, suitable for cell culture

biological source

(Collagen solution from Bovine hide)

Quality Level

100

sterility

sterile-filtered

Assay

>99% (SDS-PAGE Electrophoresis – Silver Stain, SDS-PAGE)

form

solution

packaging

pkg of 20 mL

technique(s)

cell culture | mammalian: suitable

solubility

water: miscible

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

FibriCol® collagen is approximately 97% Type I collagen with the remainder being comprised of Type III collagen. It contains a high monomer content as measured by gel permeation chromatography.

It is ideal for applications where high concentrations of collagen are needed. FibriCol® collagen is provided in a 20 mL volume and is contained in user-friendly packaging for use and storage. FibriCol® is sterile filtered and is supplied as a ready to use solution.

Application

FibriCol® has been used:

  • in the preparation of liposome-loaded co-gels to treat methicillin-resistant Staphylococcus aureus (MRSA) infections in vitro and in vivo
  • in the preparation of gelatin-methacrylate (gelMA)-collagen gels to study the effects of stiffness and fiber density on cellular behavior in breast cancer cell lines
  • in the preparation of collagen hydrogels to study its effects on macrophage response in partial thickness abdominal wall defect rat models

Legal Information

FibriCol is a registered trademark of Advanced BioMatrix, Inc.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Host macrophage response to injectable hydrogels derived from ECM and ?-helical peptides
Nazia M, et al.
Acta Biomaterialia, 111, 141-152 (2020)
Anthony J Berger et al.
Biomaterials, 141, 125-135 (2017-07-07)
The extracellular microenvironment provides critical cues that guide tissue development, homeostasis, and pathology. Deciphering the individual roles of these cues in tissue function necessitates the development of physically tunable culture platforms, but current approaches to create such materials have produced
Raj Kumar Thapa et al.
Acta biomaterialia, 103, 115-128 (2019-12-18)
Wound infections are a significant clinical problem affecting millions of people worldwide. Topically applied antibacterial formulations with longer residence time and controlled antimicrobial release would offer significant benefits for improved prevention and treatment of infected wounds. In this study, we

Articles

Attachment Factors for Three-dimensional Cell Culture

The extracellular matrix (ECM) and its attachment factor components are discussed in this article in relation to their function in structural biology and their availability for in vitro applications.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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