50020
β-Glycerol phosphate disodium salt pentahydrate
≥98.0% (NT)
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Synonym(s):
β-GP, β-glycerolphosphate, Disodium β-glycerol phosphate pentahydrate, glycerol-2-phosphate
Empirical Formula (Hill Notation):
C3H7Na2O6P · 5H2O
CAS Number:
Molecular Weight:
306.11
Beilstein:
3744328
EC Number:
MDL number:
UNSPSC Code:
41141710
PubChem Substance ID:
NACRES:
NA.25
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Quality Level
Assay
≥98.0% (NT)
form
solid
impurities
≤2% L-α-glycerol phosphate
loss
26-32% loss on drying
solubility
H2O: 0.1 g/mL, clear, colorless
storage temp.
2-8°C
SMILES string
O.O.O.O.O.[Na+].[Na+].OCC(CO)OP([O-])([O-])=O
InChI
1S/C3H9O6P.2Na.5H2O/c4-1-3(2-5)9-10(6,7)8;;;;;;;/h3-5H,1-2H2,(H2,6,7,8);;;5*1H2/q;2*+1;;;;;/p-2
InChI key
PEMUISUYOHQFQH-UHFFFAOYSA-L
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Application
β-Glycerolphosphate (Glycerol-2-Phosphate) is used in the development of hydrogels and scaffolds that have applications in tissue engineering and cell growth and differentiation.
Biochem/physiol Actions
Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression
Other Notes
Substrate for myo-inositol-1-phosphatase from bovine brain
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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A Sanghani-Kerai et al.
Bone & joint research, 6(6), 358-365 (2017-06-04)
Cellular movement and relocalisation are important for many physiologic properties. Local mesenchymal stem cells (MSCs) from injured tissues and circulating MSCs aid in fracture healing. Cytokines and chemokines such as Stromal cell-derived factor 1(SDF-1) and its receptor chemokine receptor type
Yoshitomo Honda et al.
Scientific reports, 3, 3420-3420 (2013-12-07)
Stem cell-based disease modeling presents unique opportunities for mechanistic elucidation and therapeutic targeting. The stable induction of fate-specific differentiation is an essential prerequisite for stem cell-based strategy. Bone morphogenetic protein 2 (BMP-2) initiates receptor-regulated Smad phosphorylation, leading to the osteogenic
Yung-Hsin Cheng et al.
Tissue engineering. Part A, 16(2), 695-703 (2009-09-23)
Injectable hydrogel is one of the great interests for tissue engineering and cell encapsulation. In the study, the gelatin molecules were added to the thermosensitive chitosan/beta-glycerol phosphate (C/GP) disodium salt hydrogels to form chitosan/gelatin/beta-glycerol phosphate (C/G/GP) disodium salt hydrogels which
Cristiane Machado Mengatto et al.
PloS one, 6(1), e15848-e15848 (2011-01-26)
Successful dental and orthopedic implants require the establishment of an intimate association with bone tissue; however, the mechanistic explanation of how biological systems accomplish osseointegration is still incomplete. We sought to identify critical gene networks involved in osseointegration by exploring
Liesbet Lodewyckx et al.
Arthritis research & therapy, 14(1), R16-R16 (2012-01-24)
The aim of this research was to study molecular changes in the articular cartilage and subchondral bone of the tibial plateau from mice deficient in frizzled-related protein (Frzb) compared to wild-type mice by transcriptome analysis. Gene-expression analysis of the articular
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