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44977

Sigma-Aldrich

DISBAC2(3), Voltage Sensitive Probe

≥98% (HPLC)

Synonym(s):

5-[3-(1,3-Diethylhexahydro-4,6-dioxo-2-thioxo-5-pyrimidinyl)-2-propen-1-ylidene]-1,3-diethyldihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione, Bis(1,3-diethylthiobarbituric acid)trimethine oxonol

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About This Item

Empirical Formula (Hill Notation):
C19H24N4O4S2
CAS Number:
47623-98-3
Molecular Weight:
436.55
Beilstein:
1232950
EC Number:
256-325-5
MDL number:
MFCD07437858
UNSPSC Code:
12352108
PubChem Substance ID:
329756577
NACRES:
NA.32

Quality Level

100

Assay

≥98% (HPLC)

fluorescence

λex 535 nm; λem 560 nm in DMSO

suitability

complies for Infrared spectrum

storage temp.

−20°C

SMILES string

CCN1C(=O)C(\C=C\C=C2\C(=O)N(CC)C(=S)N(CC)C2=O)C(=O)N(CC)C1=S

InChI

1S/C19H24N4O4S2/c1-5-20-14(24)12(15(25)21(6-2)18(20)28)10-9-11-13-16(26)22(7-3)19(29)23(8-4)17(13)27/h9-12H,5-8H2,1-4H3/b10-9+

InChI key

VJYNRXFXHKIGLT-MDZDMXLPSA-N

Application

DISBAC2(3), Voltage Sensitive Probe is used for single-cell fluorescence imaging of transmembrane conductance and potential change.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0621
BCCF8360
BCCD1917
BCBH2187V

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Alexander S Tatikolov et al.
Biophysical chemistry, 107(1), 33-49 (2004-02-12)
Non-covalent interactions between polymethine dyes of various types (cationic and anionic thiacarbocyanines as well as anionic oxonols and tetracyanopolymethines) and human serum albumin (HSA) were studied by means of absorption, fluorescence and circular dichroism (CD) spectroscopies. Complexation with the protein
In situ study of the membrane potential in microvascular endothelial cells using a fluorescent probe.
K Miao et al.
Microvascular research, 48(1), 135-142 (1994-07-01)
N Minami et al.
Journal of neural transmission. General section, 97(1), 65-72 (1994-01-01)
Effects of cyclic AMP on membrane potentials were examined by measuring the changes of bis-oxonol fluorescence in bovine adrenal medullary chromaffin cells. 8-Bromo cyclic AMP (8Br-cAMP) or forskolin caused a gradual and long lasting increase of the fluorescence intensity. The
V Dall'Asta et al.
Experimental cell research, 231(2), 260-268 (1997-03-15)
Confocal laser scanning microscopy (CLSM) was employed to visualize and measure membrane potential changes in several types of cultured adherent cells, such as human fibroblasts, mouse mammary tumor C127 cells, and human saphenous vein endothelial cells, preloaded with the anionic
M K Tanner et al.
Cytometry, 14(1), 59-69 (1993-01-01)
Immunosuppression by the fungal metabolite cyclosporin A (CsA) is characterized by functional inhibition, rather than destruction of cells. Because activation of immune cells involves intracellular signalling events associated with modulations of cell transmembrane potential (TMP), we tested the ability of
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