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Merck
CN

40667

Zinpyr-1

≥95.0% (HPCE)

Synonym(s):

4′,5′-Bis[bis(2-pyridylmethyl)aminomethyl]-2′,7′-dichlorofluorescein

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About This Item

Empirical Formula (Hill Notation):
C46H36Cl2N6O5
CAS Number:
288574-78-7
Molecular Weight:
823.72
UNSPSC Code:
12352200
PubChem Substance ID:
57650010
MDL number:
MFCD04039712

Key Documents

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InChI

1S/C46H36Cl2N6O5/c47-39-21-35-41(33-15-1-2-16-34(33)46(57)58)36-22-40(48)43(56)38(28-54(25-31-13-5-9-19-51-31)26-32-14-6-10-20-52-32)45(36)59-44(35)37(42(39)55)27-53(23-29-11-3-7-17-49-29)24-30-12-4-8-18-50-30/h1-22,55H,23-28H2,(H,57,58)

SMILES string

OC(=O)c1ccccc1C2=C3C=C(Cl)C(=O)C(CN(Cc4ccccn4)Cc5ccccn5)=C3Oc6c(CN(Cc7ccccn7)Cc8ccccn8)c(O)c(Cl)cc26

InChI key

NKEYRLVORYSIBB-UHFFFAOYSA-N

assay

≥95.0% (HPCE)

fluorescence

λex 492 nm; λem 527 nm in PBS, Zn2+

storage temp.

−20°C

Application

Suitable for the fluorometric detection of zinc.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBK3494V
1234145

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The Journal of experimental medicine, 214(12), 3507-3518 (2017-10-27)
The intestinal microbial ecosystem is actively regulated by Paneth cell-derived antimicrobial peptides such as α-defensins. Various disorders, including graft-versus-host disease (GVHD), disrupt Paneth cell functions, resulting in unfavorably altered intestinal microbiota (dysbiosis), which further accelerates the underlying diseases. Current strategies
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DNA hypermethylation is one of the most common epigenetic modifications in prostate cancer (PCa). Several studies have delineated sarcosine as a PCa oncometabolite that increases the migration of malignant prostate cells while decreasing their doubling time. Here, we show that
Eugene Roscioli et al.
American journal of physiology. Lung cellular and molecular physiology, 313(3), L453-L465 (2017-06-10)
The proper regulation of zinc (Zn) trafficking proteins and the cellular distribution of Zn are critical for the maintenance of autophagic processes. However, there have been no studies that have examined Zn dyshomeostasis and the disease-related modulation of autophagy observed
Yarden Golan et al.
The Journal of biological chemistry, 291(26), 13546-13559 (2016-05-04)
A gradually increasing number of transient neonatal zinc deficiency (TNZD) cases was recently reported, all of which were associated with inactivating ZnT2 mutations. Here we characterized the impact of three novel heterozygous ZnT2 mutations G280R, T312M, and E355Q, which cause
Marc Diedisheim et al.
Molecular metabolism, 10, 74-86 (2018-02-24)
Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets. Fibroblast growth factor 2 (FGF2) treatment reduced
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