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Safety Information

39197

Sigma-Aldrich

N-Dansylethylenediamine

suitable for fluorescence

Synonym(s):

N-(2-Aminoethyl)-5-dimethylamino-1-naphthalenesulfonamide, N-(2-Aminoethyl)dansylamide, DNSEDA, NSC 666752

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About This Item

Empirical Formula (Hill Notation):
C14H19N3O2S
CAS Number:
35060-08-3
Molecular Weight:
293.38
Beilstein:
2817535
MDL number:
MFCD00467523
UNSPSC Code:
12352202
PubChem Substance ID:
329755827
NACRES:
NA.32

Assay

≥90% (TLC)

solubility

methanol: 1 mg/mL, clear, slightly yellow to deep yellow

fluorescence

λex 360 nm; λem 530 nm±10 nm in methanol

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCN

InChI

1S/C14H19N3O2S/c1-17(2)13-7-3-6-12-11(13)5-4-8-14(12)20(18,19)16-10-9-15/h3-8,16H,9-10,15H2,1-2H3

InChI key

CSJXLKVNKAXFSI-UHFFFAOYSA-N

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Precautionary Statements

P261 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBK3056V

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Emma L Doyle et al.
Journal of the American Chemical Society, 125(15), 4593-4599 (2003-04-10)
The binding of copper(II) ions to membrane-bound synthetic receptors has been investigated. Complexation fitted a 4:1 receptor:copper(II) model, and the observed binding constants are significantly enhanced at the membrane relative to solution; these effects can be explained by the lower
E Kim et al.
Biophysical journal, 70(3), 1439-1446 (1996-03-01)
Actin labeled at Gln-41 with dansyl ethylenediamine (DED) via transglutaminase reaction was used for monitoring the interaction of myosin subfragment 1 (S1) with the His-40-Gly-42 site in the 38-52 loop on F-actin. Proteolytic digestions of F-actin with subtilisin and trypsin
E Kim et al.
Biophysical journal, 69(5), 2024-2032 (1995-11-01)
Gln-41 on G-actin was specifically labeled with a fluorescent probe, dansyl ethylenediamine (DED), via transglutaminase reaction to explore the conformational changes in subdomain 2 of actin. Replacement of Ca2+ with Mg2+ and ATP with ADP on G-actin produced large changes
Edna Blotnick et al.
BMC biochemistry, 18(1), 3-3 (2017-03-08)
Histatins are histidine rich polypeptides produced in the parotid and submandibular gland and secreted into the saliva. Histatin-3 and -5 are the most important polycationic histatins. They possess antimicrobial activity against fungi such as Candida albicans. Histatin-5 has a higher
E Kim et al.
Biophysical journal, 71(4), 1914-1919 (1996-10-01)
The recently reported structural connectivity in F-actin between the DNase I binding loop on actin (residues 38-52) and the C-terminus region was investigated by fluorescence and proteolytic digestion methods. The binding of copper to Cys-374 on F- but not G-actin
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