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389M-1

Sigma-Aldrich

Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody

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UNSPSC Code:
12352116
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

GS-6, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (389M-14)
vial of 0.5 mL concentrate (389M-15)
bottle of 1.0 mL predilute (389M-17)
vial of 1.0 mL concentrate (389M-16)
bottle of 7.0 mL predilute (389M-18)

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG2a

control

hepatocellular carcinoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... GLUL(2752)

Related Categories

General description

Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver. In normal liver, GS expression is seen in centrilobular (zone 3) hepatocytes, but not in mid-zone (zone 2) or periportal (zone 3) hepatocytes. Glutamine synthetase immunohistochemistry is also positive in neoplasms of hepatocyte origin, such as hepatocellular carcinoma (HCC) and hepatocellular adenoma, making it useful for identifying these tumors.

Quality


IVD
IVD
IVD
RUO

Linkage

Glutamine Synthetase Positive Control Slides, Product No. 389S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

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Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Luca Di Tommaso et al.
Hepatology (Baltimore, Md.), 45(3), 725-734 (2007-02-28)
Hepatocellular nodules in cirrhosis include regenerative (large regenerative, LRN) and dysplastic (low and high grade, LGDN and HGDN) nodules, early and grade 1 HCC (eHCC-G1), and overt HCC. The differential diagnosis may be particularly difficult when lesions such as HGDN

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