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Merck
CN

36798

7-(Diethylamino)coumarin-3-carbohydrazide

BioReagent, suitable for fluorescence, ≥95% (HPCE)

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O3
CAS Number:
100343-98-4
Molecular Weight:
275.30
UNSPSC Code:
12352125
NACRES:
NA.32
PubChem Substance ID:
57649662
MDL number:
MFCD00467583
Beilstein/REAXYS Number:
5574454

Key Documents

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Product Name

7-(Diethylamino)coumarin-3-carbohydrazide, BioReagent, suitable for fluorescence, ≥95% (HPCE)

InChI

1S/C14H17N3O3/c1-3-17(4-2)10-6-5-9-7-11(13(18)16-15)14(19)20-12(9)8-10/h5-8H,3-4,15H2,1-2H3,(H,16,18)

SMILES string

CCN(CC)c1ccc2C=C(C(=O)NN)C(=O)Oc2c1

InChI key

LYBMHAINSFEHRL-UHFFFAOYSA-N

product line

BioReagent

assay

≥95% (HPCE)

solubility

DMF: soluble
acetonitrile: soluble
chloroform: soluble
methanol: soluble

fluorescence

λex 450 nm; λem 468 nm in methanol

suitability

suitable for fluorescence

Quality Level

100

Application

7-(Diethylamino)coumarin-3-carbohydrazide is used for derivatization and detection of carboxylic acid and carbonylated molecules such as lipid peroxidation products (LPP) by electrospray ionization-mass spectrometry (ESI-MS) in positive ion mode. It may be used as a fluorescent label for the determination of lipid aldehydes in food products by normal phase liquid chromatography (NPLC) coupled to ESI-MS and fluorescent detector (FLD) and for the derivatization of monoterpene alcohols in urine prior to analysis by high performance liquid chromatography(HPLC) with FLD coupled to ESI-MS.

General description

7-(Diethylamino)coumarin-3-carbohydrazide is a coumarin-hydrazide reagent typically used as a fluorescent chemical probe for labeling of cellular carbonyls.

Other Notes

Derivatizing agent for carboxylic acid detection

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN3482
BCCM2009
BCCH0909
BCCF3603
BCBW6081

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Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry
Milic I, et al.
Analytical Chemistry, 85(1), 156-162 (2012)
M.L. Grayeski et al.
Analytical Chemistry, 59, 1203-1203 (1987)
Ivana Milic et al.
Analytical chemistry, 85(1), 156-162 (2012-11-29)
Reactive oxygen species (ROS) and other oxidative agents such as free radicals can oxidize polyunsaturated fatty acids (PUFA) as well as PUFA in lipids. The oxidation products can undergo consecutive reactions including oxidative cleavages to yield a chemically diverse group
Roland J W Meesters et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 875(2), 444-450 (2008-10-11)
A method was developed for the determination of the monoterpene alcohols verbenol, myrtenol, perillyl alcohol, alpha-terpineol, Delta(3)-carene-10-ol, thymol and p-alpha,alpha-trimethylbenzylalcohol in urine samples. After an enzymatic cleavage of their glucuronide- and sulfate conjugates the monoterpene alcohols were converted in the
Selective labeling for the identification and semi-quantification of lipid aldehydes in food products
Hollebrands B, et al.
Analytical and Bioanalytical Chemistry, 85(1), 1-9 (2018)
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