Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

363A-1

Sigma-Aldrich

PAX-8 Rabbit Polyclonal Antibody

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (363A-14)
vial of 0.5 mL concentrate (363A-15)
bottle of 1.0 mL predilute (363A-17)
bottle of 7.0 mL predilute (363A-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry: 1:25-1:100

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... PAX8(7849)

Related Categories

General description

PAX-8 is a transcription factor expressed during the embryonic development of Müllerian organs,kidneys, and thyroid, with continued expression in some epithelial cell types of these maturetissues. PAX-8 is a useful marker for neoplasms of gynecologic, renal, and thyroidorigin. This antibody targets the N-terminus of the PAX-8 molecule. This section of the protein isshared with other PAX proteins such as PAX-5 and PAX-6; thus, some cross-reactivitywith these proteins may be observed as evidenced by the labeling of selected lymphocytes, andneuroendocrine cells.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ping Zhang et al.
Pathology international, 56(5), 240-245 (2006-05-04)
Thyroid transcription factor 1 (TTF1), thyroid transcription factor 2 (TTF2) and paired box gene 8 (Pax8) are demonstrated to play a crucial role for the differentiation and organogenesis of thyroid follicular cells. Their roles in thyroid carcinogenesis are not very
Biljana Pauzar et al.
Collegium antropologicum, 36 Suppl 2, 79-82 (2013-02-13)
US-guided fine needle aspiration cytology is currently the best diagnostic tool for thyroid nodules. However, it is not sensitive and specific enough for differentiating between benign and malignant follicular tumors. A potentially useful marker for this differentiation is the PAX8-PPARgamma
Nathan J Bowen et al.
Gynecologic oncology, 104(2), 331-337 (2006-10-27)
Epithelial ovarian carcinomas develop from ovarian surface epithelia that undergo complex differentiation to form distinguishable phenotypes resembling those of the epithelia of the female urogenital regions. While previous studies have implicated regulatory developmental homeobox (HOX) genes in this process, other
Tina Di Palma et al.
The Journal of biological chemistry, 278(5), 3395-3402 (2002-11-21)
Pax genes encode for transcription factors essential for tissue development in many species. Pax8, the only member of the family expressed in the thyroid tissue, is involved in the morphogenesis of the gland and in the transcriptional regulation of thyroid-specific
Guo-Xia Tong et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 22(9), 1218-1227 (2009-06-16)
Cell-lineage-specific transcription factors are a group of regulatory proteins expressed in embryonic, differentiated, or neoplastic cells of the same lineage and represent a valuable repertoire of tissue-specific markers for the diagnosis of human tumors. Together with PAX2, PAX8 is a
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service