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338A-7

Sigma-Aldrich

TdT Rabbit Polyclonal Antibody

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UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (338A-74)
vial of 0.5 mL concentrate (338A-75)
bottle of 1.0 mL predilute (338A-77)
vial of 1.0 mL concentrate (338A-76)
bottle of 7.0 mL predilute (338A-78)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

control

thymus

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... DNTT(1791)

Related Categories

General description

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerasethat adds nucleotides randomly to single-stranded DNA. This randomization plays a role inacquired immunity by increasing antigen receptor diversity and aiding in the generation ofimmunoglobulins and T-cell antigen receptors. TdT immunoreactivity is observed mainly in the thymus. Anti-TdT is often used to visualize lymphoblastic lymphomas and has also beenobserved in some cases of acute myeloid leukemia.

Quality


IVD
IVD
IVD
RUO

Linkage

TdT Positive Control Slides, Product No. 338S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A Practical Approach to Diagnosis, 312-316 (1990)
A Orazi et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 7(5), 582-586 (1994-06-01)
Terminal deoxynucleotidyl transferase (TdT) represents a useful marker for the diagnosis of acute lymphoblastic leukemia and lymphoblastic lymphoma. It is usually assayed in fresh tissue or cell suspensions by enzyme analysis, immunofluorescence, or immunoperoxidase. We have obtained satisfactory staining for
R A Soslow et al.
Human pathology, 28(10), 1158-1165 (1997-10-29)
We propose that 12E7 (CD99) expression, along with TdT, bcl-2, and CD34 reactivity in lymphoblastic lymphoma (LyL)/acute lymphoblastic leukemia (ALL), distinguishes this group of neoplasms from small noncleaved cell lymphomas (SNCLs) in both pediatric and adult patients, thereby narrowing the
Ewing sarcoma vs lymphoblastic leukemia.
S Hirschl
American journal of clinical pathology, 115(6), 933-934 (2001-06-08)
R C Mathewson et al.
Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association, 17(6), 835-844 (1997-11-14)
In the differential diagnosis of small round cell tumors (SRCTs), terminal deoxynucleotidyl transferase (TdT) is often used as a marker for lymphoblastic lymphomas and leukemias. However, the specificity of TdT using the avidin-biotin-immunoperoxidase (ABC) method is not well documented. To
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