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Merck
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336R-9

Synaptophysin (MRQ-40) Rabbit Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
MRQ-40, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
Species reactivity:
human
Citations:
10
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-40, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (336R-94)
vial of 0.5 mL concentrate (336R-95)
bottle of 1.0 mL predilute (336R-97)
vial of 1.0 mL concentrate (336R-96)
bottle of 7.0 mL predilute (336R-98)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

pancreas

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Quality Level

100
500

Gene Information

human ... SYP(6855)

Related Categories

Analysis Note


IVD
IVD
IVD
RUO

General description

Anti-synaptophysin reacts with neuroendocrine cells of the human adrenal medulla, pituitary,thyroid, lung, pancreas, and gastrointestinal mucosa. Positive staining is seen in neuronsof the brain. This antibody identifies normal neuroendocrine cells and neuroendocrineneoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probablycorrelates with the distribution of the antigen within neurosecretory vesicles. Antisynaptophysin is an independent, broad-range marker of neural and neuroendocrinedifferentiation.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
Synaptophysin Positive Control Slides , Product No. 336S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000514530
0000515360
0000514530
0000515360
0000482035

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Yasutaka Yamada et al.
Science translational medicine, 15(722), eadf6732-eadf6732 (2023-11-15)
Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine prostate cancer (NEPC). DNA methyltransferases (DNMTs) are highly expressed, and global DNA methylation is dysregulated in NEPC. We identified that
M Skacel et al.
Applied immunohistochemistry & molecular morphology : AIMM, 8(3), 203-209 (2000-09-12)
Histologic differential diagnosis of acinar cell carcinoma (ACC), mixed acinar-endocrine cell carcinoma (MAEC), and pancreatic endocrine tumors (PET) can be difficult but is important because of differences in their clinical behavior. This study investigates the utility of immunohistochemistry (IHC) in
Eun-Ik Son et al.
Pathology international, 53(2), 67-73 (2003-02-18)
Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non-anaplastic, four diffuse/anaplastic, three nodular/non-anaplastic and one
Michael G Conner et al.
Annals of diagnostic pathology, 6(6), 345-348 (2002-12-13)
Twenty-three patients with primary small cell carcinoma of the uterine cervix are presented. Their ages ranged between 23 and 63 years (average, 43 years). Blood spotting or vaginal bleeding was the most common clinical presentation. Histologically, the tumors were densely
K Kayser et al.
Pathology, research and practice, 183(4), 412-417 (1988-08-01)
The value of immunoreactivity of antibodies against neuronspecific enolase (NSE), bombesin (GRP), and synaptophysin (SY 38) as markers for various human lung carcinoma has been assessed. One hundred-forty-two primary bronchus carcinomas (small cell anaplastic carcinoma, epidermoid carcinoma, adeno carcinoma, and
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