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Safety Information

333R-1

Sigma-Aldrich

Spectrin (EP251) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP251, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (333R-14)
vial of 0.1 mL concentrate Research Use Only (333R-14-RUO)
vial of 0.5 mL concentrate (333R-15)
vial of 1.0 mL concentrate (333R-16)
vial of 1.0 mL concentrate Research Use Only (333R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (333R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (333R-17)
vial of 7.0 mL pre-dilute ready-to-use (333R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (333R-18-RUO)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

bone marrow

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... SPTA1(6708)

General description

Spectrin is a cytoskeletal protein which is found in muscles, red blood cells and red cell precursors. Spectrin is an actin-crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. The gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in the gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. Anti-spectrin is useful in the identification of erythrocytes and erythroid disorders.

Quality


IVD
IVD
IVD
RUO

Linkage

Spectrin Positive Control Slides, Product No. 333S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000126136
0000105164
0000091727
0000090931
0000082049

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N Terada et al.
Journal of anatomy, 190 ( Pt 3), 397-404 (1997-04-01)
A quick-freezing and deep-etching method in combination with erythrocyte splitting was used to examine the cytoplasmic aspect of whole-mount human erythrocyte membranes. Various external forces induced alterations in membrane skeletal organisation during the splitting procedure. The initial change was elongation
V Nehls et al.
The American journal of pathology, 142(5), 1565-1573 (1993-05-01)
Expression of the erythrocyte anion exchanger band 3, and ankyrin and spectrin, two cytoskeletal proteins of the red blood cell membrane, was studied by immunofluorescence using: 1) smears of human bone marrow from healthy donors and from a patient with
M Müller et al.
Journal of veterinary medicine. A, Physiology, pathology, clinical medicine, 48(1), 51-57 (2001-08-23)
In an immunohistological/cytological study of canine bone marrow, the aim was to demonstrate canine erythroid cells with the help of various commercially available antibodies against human antigens (monoclonal antibody against glycophorin A, polyclonal antibodies against haemoglobin and spectrin). In order
Y Sadahira et al.
Journal of clinical pathology, 52(12), 919-921 (2000-03-11)
To investigate whether spectrin can be used as an immunohistochemical marker for erythroid precursors in routinely processed paraffin embedded bone marrow sections. Bone marrow biopsies and clot sections were stained with rabbit antihuman erythrocyte spectrin antibodies, specific for erythroid cells

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