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Merck
CN

30058

Lipase Substrate

≥95% (HPLC)

Synonym(s):

1,2-Di-O-lauryl-rac-glycero-3-(glutaric acid 6-methylresorufin ester)

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About This Item

Empirical Formula (Hill Notation):
C45H69NO8
CAS Number:
195833-46-6
Molecular Weight:
752.03
NACRES:
NA.83
PubChem Substance ID:
57648405
UNSPSC Code:
12352204
MDL number:
MFCD08276995

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Product Name

Lipase Substrate, ≥95% (HPLC)

InChI key

FYOMYGYHAZESGQ-UHFFFAOYSA-N

SMILES string

CCCCCCCCCCCCOCC(COC(=O)CCCC(=O)Oc1ccc2N=C3C=CC(=O)C(C)=C3Oc2c1)OCCCCCCCCCCCC

InChI

1S/C45H69NO8/c1-4-6-8-10-12-14-16-18-20-22-31-50-34-38(51-32-23-21-19-17-15-13-11-9-7-5-2)35-52-43(48)25-24-26-44(49)53-37-27-28-39-42(33-37)54-45-36(3)41(47)30-29-40(45)46-39/h27-30,33,38H,4-26,31-32,34-35H2,1-3H3

assay

≥95% (HPLC)

form

powder

solubility

ethanol: soluble (10mg/mL)

fluorescence

λex 529 nm; λem 600 nm in 0.1 M Tris pH 8.4

storage temp.

2-8°C

Quality Level

100

Application

Lipase Substrate is used as substrate in a high‑throughput screening assay to measure the lipase activity in response to lipstatin production

General description

Lipase substrate (1,2-Di-O-lauryl-rac-glycero-3-(glutaric,acid 6-methylresorufin) ester, DGGR) is a chromogenic substrate for lipases. It is used in colorimetric methods to measure lipase activity. This substrate produces a red-purple compound, methylresorufin, upon digestion by the lipase enzyme.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM8479
BCCK8939
BCCJ0198
BCCF2452
BCCC9804

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Ievgeniia Ostrov et al.
Food microbiology, 82, 316-324 (2019-04-28)
Biofilm-forming Bacillus species are often involved in contamination of dairy products and therefore present a major microbiological challenge in the field of food quality and safety. In this study, we sequenced and analyzed the genomes of milk- and non-milk-derived Bacillus
Michal Híreš et al.
Current microbiology, 75(5), 580-587 (2017-12-20)
Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by the European Medicines Agency (EMA). The drug is synthesized by saturation of lipstatin, a β-lactone compound, isolated from Streptomyces toxytricini
Sébastien Cadau et al.
International journal of molecular sciences, 23(21) (2022-11-12)
Atopic dermatitis (AD), the most common inflammatory skin disorder, is a multifactorial disease characterized by a genetic predisposition, epidermal barrier disruption, a strong T helper (Th) type 2 immune reaction to environmental antigens and an altered cutaneous microbiome. Microbial dysbiosis
Yan Q Chen et al.
Journal of lipid research, 61(8), 1203-1220 (2020-06-04)
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate LPL. In human serum
Chui Boon Tee et al.
Mycopathologia, 184(2), 227-238 (2019-03-29)
Malassezia yeasts are opportunistic pathogens associated with a number of skin diseases in animals and humans. The free fatty acids released through these organisms' lipase and phospholipase activities trigger inflammation in the host; thus, these lipase and phospholipase activities are
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