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Merck
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281M-8

MART-1 (Melan A) (A103) Mouse Monoclonal Antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
A103, monoclonal
Application:
IHC (p)
Citations:
14

Key Documents

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isotype

IgG1

biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

A103, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (281M-84), vial of 0.5 mL concentrate (281M-85), bottle of 1.0 mL predilute (281M-87), vial of 1.0 mL concentrate (281M-86), bottle of 7.0 mL predilute (281M-88)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

control

melanoma

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Quality Level

100, 500

Gene Information

human ... MLANA(2315)

Related Categories

General description

MART-1 (also known as melan A) is a melanoma antigen recognized by T cells.1-2 MART-1 is a transmembrane protein present in melanocytes of normal skin, nevi, and most melanomas. MART-1 is a useful marker for identifying melanomas.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Analysis Note


IVD
IVD
IVD
RUO

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
MART-1 Positive Control Slides, Product No. 281S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000518694
0000518696
0000518696
0000518694
0000507204

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Ravi Suchak et al.
The American Journal of dermatopathology, 36(5), 387-391 (2014-01-08)
To assess the usefulness of routine melan-A immunohistochemistry (IHC) for exclusion of microinvasion in lentigo maligna (LM). One hundred and twenty cases of LM from our archives were reviewed by 2 authors with S100 protein and melan-A IHC using a
P G Coulie et al.
The Journal of experimental medicine, 180(1), 35-42 (1994-07-01)
It has been reported previously that antitumor cytolytic T lymphocyte (CTL) clones can be isolated from blood lymphocytes of HLA-A2 melanoma patients, after stimulation in vitro with autologous tumor cells, and that some of these CTL clones lyse most HLA-A2
Patricia Switten Nielsen et al.
The American Journal of dermatopathology, 33(4), 361-370 (2011-05-26)
Distinction between benign and malignant melanocytic lesions may be difficult by today's methods, even for highly skilled dermatopathologists, emphasizing the need for improved diagnostic tools. We have studied the discriminative abilities of immunohistochemical (IHC) double stains using the IHC markers
Klaus Helm et al.
Journal of cutaneous pathology, 35(10), 931-934 (2008-05-23)
Distinguishing lentigo maligna from solar lentigo, and pigmented actinic keratosis can sometimes be problematic. Melan-A is an immunohistochemical marker which that can be helpful in decorating the melanocytes of pigmented lesions. A recent report has suggested that Melan-A may spuriously
Y Kawakami et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(9), 3515-3519 (1994-04-26)
By cDNA expression cloning we have isolated a gene encoding a shared human melanoma antigen recognized by HLA-A2 restricted autologous and allogenic tumor-infiltrating lymphocytes (TILs) from patients with metastatic melanoma. By using both transient and stable expression systems, transfection of
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