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275R-3

Sigma-Aldrich

Ki-67 (MRQ-64) Rabbit Monoclonal Antibody

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MRQ-64, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (275R-34)
vial of 0.1 mL concentrate Research Use Only (275R-34-RUO)
vial of 0.5 mL concentrate (275R-35)
vial of 1.0 mL concentrate (275R-36)
vial of 1.0 mL concentrate Research Use Only (275R-36-RUO)
vial of 1.0 mL pre-dilute Research Use Only (275R-37-RUO)
vial of 1.0 mL pre-dilute ready-to-use (275R-37)
vial of 25.0 mL pre-dilute ready-to-use (275R-30)
vial of 25.0 mL pre-dilute ready-to-use Research Use Only (275R-30-RUO)
vial of 7.0 mL pre-dilute ready-to-use (275R-38)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (275R-38-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

isotype

IgG

control

Burkitt lymphoma, breast (ductl carcinoma in situ), tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

nuclear

Gene Information

human ... MKI67(4288)

Related Categories

General description

Ki-67 (MRQ-64) is an antibody designed to target Ki-67 antigen-a nuclear protein encoded by the MKI67 gene whose presence correlates with G1, S, G2, and the mitotic phases of the cell cycle.1 Though its specific role is largely postulated and still yet to be determined, Ki-67′s presence during cellular division makes it an excellent target for labeling rapidly growing malignancies.2 Given that its presence correlates with cell proliferation, the immunohistochemical labeling of Ki-67 antigen may be useful in characterizing a lesion′s growth fraction. It has been demonstrated that identifying this antigen by IHC is useful in characterizing lesions of the breast, lymphoid cells, astrocytes, and uterus.3-9

Quality

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Linkage

Ki-67 Positive Control Slides, Product No. 275S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

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Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Adi Broyde et al.
American journal of hematology, 84(6), 338-343 (2009-04-23)
Expression of Ki-67, a nuclear antigen protein present in all cycling cells, is used to determine the growth fraction of tumors. The aim of this study was to evaluate the role and prognostic significance of the Ki-67 proliferation index (PI)
Shih-Sung Chuang et al.
American journal of clinical pathology, 128(4), 558-564 (2007-09-19)
Burkitt lymphoma (BL) is characterized by c-myc translocation and CD10+/bc-2-/bcl-6+ with a very high Ki-67 proliferation index (PI). Occasional diffuse large B-cell lymphomas may exhibit a very high PI with or without a starry-sky pattern (DLBCL-HPSS). We compared 28 consecutive
E C Inwald et al.
Breast cancer research and treatment, 139(2), 539-552 (2013-05-16)
The proliferation marker Ki-67 is one of the most controversially discussed parameters for treatment decisions in breast cancer patients. The purpose of this study was to evaluate the routine use and value of Ki-67 as a prognostic marker, and to
Xiaoming Sun et al.
Chromosoma, 127(2), 175-186 (2018-01-13)
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become better understood. Ki-67 has roles in both interphase and mitotic cells, and
Klaus Mayerhofer et al.
Acta obstetricia et gynecologica Scandinavica, 83(11), 1085-1088 (2004-10-19)
The aim of the current study was to evaluate the expression of Ki-67 in uterine smooth muscle tumors, comparing leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS) and to prove the accuracy of a
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