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258024

Sigma-Aldrich

α-Tocopherol

≥95.5%

Synonym(s):

(±)-α-Tocopherol, DL-all-rac-α-Tocopherol, Vitamin E

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About This Item

Empirical Formula (Hill Notation):
C29H50O2
CAS Number:
10191-41-0
Molecular Weight:
430.71
Beilstein:
94012
EC Number:
233-466-0
MDL number:
MFCD00006848
UNSPSC Code:
12352205
eCl@ss:
34058016
PubChem Substance ID:
57648149
NACRES:
NA.28
Pricing and availability is not currently available.

biological source

synthetic

Quality Level

200

Assay

≥95.5%

form

liquid

technique(s)

HPLC: suitable

color

faint brown to brown
 yellow to very dark yellow

density

0.950 g/mL at 20 °C (lit.)

application(s)

cell analysis

storage temp.

2-8°C

SMILES string

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1

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Show Differences

1 of 4

This Item
PHR148158958V319902
乙酸乙酯 Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS

EX0240

乙酸乙酯

乙酸乙酯 Pharmaceutical Secondary Standard; Certified Reference Material

PHR1481

乙酸乙酯

乙酸乙酯 analytical standard

58958

乙酸乙酯

乙酸乙酯 ACS reagent

V319902

乙酸乙酯

assay

≥99.5% (GC)

assay

-

assay

≥99.9% (GC)

assay

-

application(s)

environmental
food and beverages
industrial qc
pharmaceutical
sample preparation

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
environmental
flavors and fragrances
food and beverages
personal care

application(s)

-

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

grade

ACS reagent, for extraction, for analytical purposes, reagent grade

grade

certified reference material, pharmaceutical secondary standard

grade

analytical standard

grade

ACS reagent

form

liquid

form

-

form

-

form

-

vapor density

3 (20 °C, vs air)

vapor density

3 (20 °C, vs air)

vapor density

3 (20 °C, vs air)

vapor density

3 (20 °C, vs air)

General description

α-Tocopherol is the active form of vitamin E.[1] It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses.[2] α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease.[1] It has antiproliferative effects.[3] It inhibits arsenite-induced damage of human fibroblasts.[4]

Application

α-Tocopherol has been used:
  • as a standard to determine its concentration by reverse-phase high-performance liquid chromatography[5][6]
  • to study its rescue effects on chlorine dioxide (ClO2) cytotoxicity[7]
  • to assess its protective effects on acetaminophen (APAP)-mediated liver damage[8]

Biochem/physiol Actions

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCW5964
    MKCX1479
    0000422457
    0000311457
    0000356109

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    Nutritional deficiencies and syndromes associated with alcoholism
    Textbook of Clinical Neurology (Third Edition), 897-917 (2007)
    Effect of vitamin E on oxidative stress level in blood, synovial fluid, and synovial tissue in severe knee osteoarthritis: a randomized controlled study
    Tantavisut S, et al.
    BMC Musculoskelet. Disord., 18(1), 281-281 (2017)
    Early Diagnosis and Treatment of Cancer Series: Prostate Cancer E-Book: Expert Consult - Online and Print, 897-917 (2015)
    Oxidative stress induced by chlorine dioxide as an insecticidal factor to the Indian meal moth, Plodia interpunctella
    Kumar S, et al
    Pesticide Biochemistry and Physiology, 124, 48-59 (2015)
    Glycosphingolipids Prevent APAP and HMG-CoA Reductase Inhibitors-mediated Liver Damage: A Novel Method for ?Safer Drug? Formulation that Prevents Drug-induced Liver Injury
    Mizrahi M, et al.
    Journal of clinical and translational hepatology, 6(2), 1-8 (2018)
    View All Related Papers

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    Dietary Antioxidants

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