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17927

Sigma-Aldrich

9-Oxo-10(9H)-acridineacetic acid

for HPLC derivatization, ≥99.0% (T)

Synonym(s):

(9,10-Dihydro-9-oxo-10-acridinyl)acetic acid, 10-(Carboxymethyl)-9(10H)acridone

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About This Item

Empirical Formula (Hill Notation):
C15H11NO3
CAS Number:
38609-97-1
Molecular Weight:
253.25
Beilstein:
227508
MDL number:
MFCD00157050
UNSPSC Code:
12352106
PubChem Substance ID:
329751585
NACRES:
NA.32

grade

for HPLC derivatization

Quality Level

100

Assay

≥99.0% (T)

form

solid

mp

~289 °C (dec.)

SMILES string

OC(=O)CN1c2ccccc2C(=O)c3ccccc13

InChI

1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)

InChI key

UOMKBIIXHQIERR-UHFFFAOYSA-N

Application

9-Oxo-10(9H)-acridineacetic acid and its analogs are used to study their potential activity as interferon inducers.

Other Notes

Reagent for pre-column derivatization of amino acids for fluorescent determination in HPLC; Building block in pharmaceutics

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF7447

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Tolerance or hyperreactivity to interferon induction by sodium salt of 9-oxo-10-acridineacetic acid and analogs in mice and in the mouse macrophage cultures.
Szulc B, Inglot AD, Inglot O.
Arch. Immunol. Ther. Exp., 35, 389-395 (1987)
V M Frolov et al.
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 57(5-6), 18-27 (2012-11-20)
The use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic
V M Frolov et al.
Likars'ka sprava, (1-2)(1-2), 102-107 (2012-10-06)
The effect of the immunotropic drug cycloferon and herbal medicine resources on the basis of Cynara scolimus L. on the blood cytokine profile in the patients with chronic viral hepatitis C (CVHC) in medical rehabilitation (MR) period. Established that prior
D S Sukhanov et al.
Patologicheskaia fiziologiia i eksperimental'naia terapiia, (1)(1), 65-69 (2013-06-29)
The results of pre-clinical research of cycloferon, remaxol and runihol on the model of experimental generalized tuberculosis, caused by the MBT with a different spectrum of drug sensitivity are presented. A considerable increase of the curative effect of the therapy
D S Sukhanov et al.
Eksperimental'naia i klinicheskaia farmakologiia, 75(9), 32-36 (2012-11-20)
The results of an experimental study of the efficiency of cycloferon included in a complex chemotherapy of generalized drug-resistant mycobacterium tuberculosis (MBT) are presented. It is established that cycloferon (3.6 mg/kg) produces a significant therapeutic effect, which is manifested by
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