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174M-1

Sigma-Aldrich

CD74 (LN2) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

diluted ascites fluid

antibody product type

primary antibodies

clone

LN2, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (174M-14)
vial of 0.5 mL concentrate (174M-15)
bottle of 1.0 mL predilute (174M-17)
vial of 1.0 mL concentrate (174M-16)
bottle of 7.0 mL predilute (174M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

isotype

IgG1

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... CD74(972)

General description

Anti-CD74 stains predominantly germinal center lymphocytes and B-cell lymphomas but rarely T-cell lymphomas. It stains the cell membrane but a paranuclear globular labeling is also noted. It is a useful addition to the lymphoma phenotyping panel. Anti-CD74 has been shown to be useful in differentiating atypical fibroxanthoma from malignant fibrous histiocytoma, as well as small cell lung carcinomas from non-small cell lung carcinomas.

Quality


IVD
IVD
IVD
RUO

Linkage

CD74 Positive Control Slides, Product No. 174S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000090473
0000082135
0000069203
0000061485
0000052896

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C W Ross et al.
Cancer, 70(10), 2517-2523 (1992-11-15)
There is great diversity in the clinical presentation of CD30 (Ki-1)-positive, anaplastic large cell lymphoma (ALCL). The authors report two patients in whom the clinical and morphologic features mimicked gastrointestinal carcinoma. Surgical pathology specimens were examined using standard histologic techniques.
R Lazova et al.
Cancer, 79(11), 2115-2124 (1997-06-01)
In this study, the authors examined the expression of LN-2, an antigen expressed by B cells, macrophages, and Reed-Sternberg cells, in a variety of spindle cell lesions of the skin to determine whether LN-2 immunoreactivity can be used to differentiate
H L Ioachim et al.
The American journal of surgical pathology, 20(1), 64-71 (1996-01-01)
In the course of investigating 30 monoclonal antibodies (MAbs) for their potential reactivity with 25 lung tumors of different histologic types, we found that three MAbs commonly used for their specificities for lymphoid markers were highly reactive with non-small-cell carcinomas
M Ohsawa et al.
Journal of clinical pathology, 47(10), 928-932 (1994-10-01)
AIMS--To evaluate the immunoreactivities of neoplastic and non-neoplastic monocytoid B cells (MBC) and compare them with hairy cell leukemia (HCL) and mantle cell lymphoma (MCL). METHODS--An immunohistochemical study of paraffin wax embedded sections was done on surgically resected specimens of
X Tang et al.
Pathology international, 45(1), 34-44 (1995-01-01)
Extensive immunohistochemical analyses of the hyperplastic human palatine tonsil disclosed variegated B cell phenotypes on the lymphoid cells among the crypt epithelium. The reticular epithelial network was evident by cytokeratin immunostaining. The reticular epithelium near the crypt lumen was positive
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