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Merck
CN

16758

Poloxamer 407

purified, non-ionic

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

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About This Item

CAS Number:
9003-11-6
UNSPSC Code:
12352104
NACRES:
NA.25
MDL number:
MFCD00082049

Key Documents

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Product Name

Poloxamer 407, purified, non-ionic

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

form

powder

quality

purified

impurities

≤1.0% water

pH

5.0-7.5

solubility

soluble, clear, colorless

cation traces

Al: ≤5 mg/kg
As: ≤0.05 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤50 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤1000 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

UV absorption

λ: 260 nm Amax: ≤0.3
λ: 280 nm Amax: ≤0..2

suitability

no residue for filter test

storage temp.

2-8°C

Quality Level

100

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Application

Poloxamer 407 has been used:
  • as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
  • for VLDL secretion assay in mice
  • to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Biochem/physiol Actions

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

General description

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6554
BCCM7834
BCCL9329
BCCL1177
BCCL1176

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