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146M-1

Sigma-Aldrich

CD45R (MB1) Mouse Monoclonal Antibody

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

MB1, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (146M-14)
vial of 0.5 mL concentrate (146M-15)
bottle of 1.0 mL predilute (146M-17)
vial of 1.0 mL concentrate (146M-16)
bottle of 7.0 mL predilute (146M-18)

manufacturer/tradename

Cell Marque®

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

isotype

IgG1

control

tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

membranous

Gene Information

human ... PTPRC(5788)

General description

MB1 antibody stains preferentially B-cells and their neoplasms but is less specific as it will also react with some T-cell lymphomas and non-lymphoid tumors. The antigen for this antibody is in the membrane of all B-cells with the exception of plasma cells and some mature T-cells.

Quality


IVD
IVD
IVD
RUO

Linkage

CD45R Positive Control Slides, Product No. 146S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Regulatory Information

监管及禁止进口产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000116460
0000078289
0000075095
0000063854
0000035959

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S Poppema et al.
The American journal of pathology, 127(3), 418-429 (1987-06-01)
The absence of reactivity on routinely prepared tissue sections has hampered the use of monoclonal antileukocyte antibodies in diagnostic histopathology. Here we describe five new antibodies reactive with leukocyte subsets in formaldehyde-fixed, paraffin-embedded tissue sections. Antibody MT1 is reactive with
A J Norton et al.
Histopathology, 10(12), 1243-1260 (1986-12-01)
Formalin fixed and paraffin wax embedded tissue from 24 cases of T-cell lymphoma diagnosed using immunocytochemistry on cryostat sections was examined using a panel of eight monoclonal and three polyclonal antisera. The monoclonal antibodies UCHL1 and MT1 proved to be
C S Scott et al.
Clinical and experimental immunology, 86(3), 500-505 (1991-12-01)
The differential expression of various membrane CD45R isoforms by normal lymphocyte populations is known to be closely associated with distinct immunoregulatory functions. Abnormal patterns of CD45R expression have been reported in patients with common variable immunodeficiency and HIV infection, and
K P West et al.
The Journal of pathology, 150(2), 89-101 (1986-10-01)
The monoclonal antibodies MB1 and MT1, which detect B cells and T cells respectively, have been applied to human lymphoid tissues. The distribution of staining within paraffin sections was compared with that observed using frozen sections and was found to
P S Master et al.
International journal of hematology, 55(3), 235-242 (1992-06-01)
The membrane expression of CD45R isoforms by leukaemic blasts from 92 cases of acute myeloid (AML) and 12 cases of lymphoblastic leukaemia was analysed by single and two-colour flow cytometry. Compared to normal mature granulocytes, which invariably expressed UCHL1 (CD45RO)
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