All Photos(3)
Synonym(s):
1-carboxy-n,n,n-trimethylmethanaminium hydroxide, 2-(trimethylammonio)acetate hydrate, glycine betaine hydrate
Linear Formula:
(CH3)3N+CH2COO- · H2O
CAS Number:
Molecular Weight:
135.16
Beilstein:
3626258
EC Number:
MDL number:
UNSPSC Code:
51171529
PubChem Substance ID:
NACRES:
NA.25
Recommended Products
Quality Level
Assay
≥99.0% (NT)
form
solid
solubility
H2O: 0.1 g/mL, clear, colorless
storage temp.
2-8°C
SMILES string
O.C[N+](C)(C)CC([O-])=O
InChI
1S/C5H11NO2.H2O/c1-6(2,3)4-5(7)8;/h4H2,1-3H3;1H2
InChI key
NJZRLXNBGZBREL-UHFFFAOYSA-N
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Application
Betaine monohydrate:
- is suitable for use to improve the PCR amplification of GC-rich DNA sequences by reducing the formation of secondary structure caused by GC-rich regions
- is suitable for use as a component of PCR reaction mixture
- is suitable for use in a study to identify yield enhancers of PCR
- has been used to study nitrogen balance and nutrient digestibility in piglets fed diets deficient in methionine and low in compatible osmolytes
- has also been used to compare the effects of pressure on three layered hydrates
Biochem/physiol Actions
End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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M Kovárová et al.
Nucleic acids research, 28(13), E70-E70 (2000-06-28)
Tetramethylammonium (TMA) chloride, dimethyl sulfoxide and formamide are known to increase, under certain conditions, the specificity and efficiency of the polymerase chain reaction (PCR). We compared the ability of several TMA derivatives and some other reagents to increase the specificity
Meike Eklund et al.
Archives of animal nutrition, 60(4), 289-300 (2006-08-23)
A balance experiment was carried out to investigate the effects of betaine monohydrate (BET) or betaine derived from condensed molasses solubles (CMS) as a substitute for methionine and choline on nitrogen (N) balance and total tract nutrient digestibility in weaned
Russell D L Johnstone et al.
Acta crystallographica. Section B, Structural science, 65(Pt 6), 731-748 (2009-11-20)
We report the effect of pressure on the crystal structures of betaine monohydrate (BTM), L-cysteic acid monohydrate (CAM) and S-4-sulfo-L-phenylalanine monohydrate (SPM). All three structures are composed of layers of zwitterionic molecules separated by layers of water molecules. In BTM
Theodore Spilker et al.
Journal of clinical microbiology, 50(9), 3010-3015 (2012-07-13)
The genus Achromobacter currently is comprised of seven species, including Achromobacter xylosoxidans, an opportunistic and nosocomial pathogen that displays broad-spectrum antimicrobial resistance and is recognized as causing chronic respiratory tract infection in persons with cystic fibrosis (CF). To enable strain
Daniel A Shoskes et al.
The Journal of urology, 168(1), 331-335 (2002-06-07)
The chronic pelvic pain syndrome is a common disorder of unknown etiology. Elevated cytokines in prostate fluid and semen are frequent findings. We studied genetic polymorphisms that can alter cytokine gene expression in men with the chronic pelvic pain syndrome.
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