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Merck
CN

137256

MES monohydrate

EMPROVE® EVOLVE

Synonym(s):

MES, 2-(N-Morpholino)ethanesulfonic acid, 4-Morpholineethanesulfonic acid monohydrate

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About This Item

Linear Formula:
C6H13NO4S · H2O
CAS Number:
145224-94-8
Molecular Weight:
213.25
UNSPSC Code:
12161700
Beilstein/REAXYS Number:
6350956
MDL number:
MFCD00149409

Key Documents

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Product Name

MES monohydrate, EMPROVE® EVOLVE

InChI key

MIIIXQJBDGSIKL-UHFFFAOYSA-N

SMILES string

O.OS(=O)(=O)CCN1CCOCC1

InChI

1S/C6H13NO4S.H2O/c8-12(9,10)6-3-7-1-4-11-5-2-7;/h1-6H2,(H,8,9,10);1H2

biological source

synthetic

product line

EMPROVE® EVOLVE

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin, microbial, and trace metals, tested

pH

5.5-6.7

useful pH range

5.5-6.7

pKa (25 °C)

6.1

pKa 

6.1

mp

>300 °C (lit)
>300 °C (lit.)

suitability

suitable for manufacturing use

foreign activity

Cytotoxicity, DNase, NICKase, RNase, and Protease; tested

storage temp.

2-30°C

Quality Level

400

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Application

MES is a biological buffer often referred to as a “Good′s” buffer .The pKa of MES is 5.96 which makes MES an ideal candidate for cell culture media and protein based buffer formulations to maintain a stable environment in solution. MES is considered to be non-toxic to culture cell lines, highly water soluble and provides high solution clarity.MES is used in cell culture media, biopharmaceutical buffer formulations (both upstream and downstream), and diagnostic reagents. MES based buffers are used in purification bioprocesses of antibodies, peptides, proteins, blood components and growth factors.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
CDBG8487
CDBG8577
CDBG8575
CDBG8488
CDBG8236

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