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Merck
CN

13135

N-Benzoyl-L-tyrosine p-amidobenzoic acid sodium salt

lyophilized, ≥98.0% (sum of enantiomers, HPLC)

Synonym(s):

N-Benzoyl-L-tyrosyl-4-aminobenzoic acid sodium salt, Bentiromide

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About This Item

Linear Formula:
C23H19N2O5Na
CAS Number:
41748-47-4
Molecular Weight:
444.41
NACRES:
NA.83
PubChem Substance ID:
57647058
UNSPSC Code:
12352204
EC Number:
255-530-7
MDL number:
MFCD00042647

Key Documents

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Product Name

N-Benzoyl-L-tyrosine p-amidobenzoic acid sodium salt, lyophilized, ≥98.0% (sum of enantiomers, HPLC)

InChI key

HEJYVLSWQWPKPQ-BDQAORGHSA-M

InChI

1S/C23H20N2O5.Na/c26-19-12-6-15(7-13-19)14-20(25-21(27)16-4-2-1-3-5-16)22(28)24-18-10-8-17(9-11-18)23(29)30;/h1-13,20,26H,14H2,(H,24,28)(H,25,27)(H,29,30);/q;+1/p-1/t20-;/m0./s1

SMILES string

[Na+].Oc1ccc(C[C@H](NC(=O)c2ccccc2)C(=O)Nc3ccc(cc3)C([O-])=O)cc1

assay

≥98.0% (sum of enantiomers, HPLC)

form

powder or crystals

optical activity

[α]20/D +45±2°, c = 1% in DMF/H2O 1:1

quality

lyophilized

mp

~210 °C (dec.)

solubility

water: 0.25 g/5mL, clear to slightly hazy

storage temp.

2-8°C

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General description

N-Benzoyl-L-tyrosine p-amidobenzoic acid acts as a substrate for peptide hydrolases present in the human small intestinal mucosa. Its degradation to p-aminobenzoic acid helps to assess the pancreatic and renal functionality.

Other Notes

Hydrolysis of benzol-tyrosyl-p-aminobenzoic acid by a human intestinal microvillar peptidase; Substrate for the assay of chymotrypsin in crude biological materials.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BGBC2180V
1357366V
1357366
1325700
360668/1

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C Lang et al.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 18(9), 551-555 (1980-09-01)
The oral pancreatic function test with N-benzoyl-L-tyrosyl-p-aminobenzoic acid was performed on 24 healthy test subjects, and its toxicity was examined. Eight patients with restricted renal function and known renal disease were also investigated. The pancreatic function test and the same
A method for the assay of chymotrypsin in crude biological materials.
A R Imondi et al.
Analytical biochemistry, 54(1), 199-204 (1973-07-01)
E E Sterchi et al.
Clinical science (London, England : 1979), 62(5), 557-560 (1982-05-01)
1. Hydrolysis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA-peptide) has been measured in soluble and particulate fractions of human small intestinal mucosa. 2. Both soluble and particulate fractions contained enzymic activity capable of splitting the PABA-peptide. In the particulate fractions this activity increased
P.W. Pemberton et al.
Biochemical Society Transactions, 13, 175-175 (1985)

Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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