Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

111R-1

Sigma-Aldrich

CD11c (EP157) Rabbit Monoclonal Primary Antibody

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

EP157, monoclonal

description

For In Vitro Diagnostic Use in Select Regions

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (111R-14)
vial of 0.1 mL concentrate Research Use Only (111R-14-RUO)
vial of 0.5 mL concentrate (111R-15)
vial of 1.0 mL concentrate (111R-16)
vial of 1.0 mL concentrate Research Use Only (111R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (111R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (111R-17)
vial of 7.0 mL pre-dilute ready-to-use (111R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (111R-18-RUO)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotype

IgG

control

hairy cell leukemia, spleen, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... ITGAX(3687)

Related Categories

General description

CD11c is an adhesion receptor of the leukocyte function-associated family of molecules. This cell surface antigen is normally expressed on granulocytes, monocytes, natural killer cells, macrophages, and small populations of T- and B-lymphocytes. Anti-CD11c detects a formalin-resistant epitope of CD11c expressed in hairy cell leukemia (HCL). HCL is a distinctive yet uncommon chronic B-cell lymphoproliferative disorder, predominantly involving the bone marrow and spleen. Besides being consistently expressed in HCL, CD11c is rarely detected in lymphomas; such as small lymphocytic lymphoma (SLL), and nodal and extranodal marginal zone lymphoma (MZL).

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Not finding the right product?  

Try our Product Selector Tool.

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Gail Jones et al.
British journal of haematology, 156(2), 186-195 (2011-11-25)
The British Committee for Standards in Haematology first produced guidelines for the diagnosis and management of hairy cell leukaemia and hairy cell leukaemia variant in 2000. This revision updates those guidelines and covers the areas of diagnosis, treatment and assessment
G Marotta et al.
Leukemia & lymphoma, 37(1-2), 145-149 (2000-03-18)
This study analyzed the expression of the beta2 integrin CD11c in 155 patients with well-characterized B-cell chronic lymphoproliferative disorders: 106 B-cell chronic lymphocytic leukemias (B-CLL), 21 hairy cell leukemias (HCL), 9 B-cell prolymphocytic leukemias (PLL) and 19 low grade non-Hodgkin's
Korinna Johrens et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 75(4), 252-256 (2008-06-27)
The diagnosis of hairy cell leukemia (HCL) and its distinction from other B-cell lymphomas can be difficult in formalin-fixed tissue. This is because the histology is not always classical, and despite having a characteristic phenotype, there are few relevant monoclonal

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service