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Sigma-Aldrich

(+)-Sodium L-ascorbate

BioXtra, ≥99.0% (NT)

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Synonym(s):
L(+)-Ascorbic acid sodium salt, Vitamin C sodium salt
Empirical Formula (Hill Notation):
C6H7NaO6
CAS Number:
134-03-2
Molecular Weight:
198.11
Beilstein:
3767246
EC Number:
205-126-1
MDL number:
MFCD00082340
UNSPSC Code:
12352205
eCl@ss:
34058010
PubChem Substance ID:
57646888
NACRES:
NA.79

product line

BioXtra

Quality Level

200

Assay

≥99.0% (NT)

form

powder or crystals

optical activity

[α]20/D +105±2°, c = 5% in H2O

loss

≤0.2% loss on drying, 110 °C

color

white

mp

220 °C (dec.) (lit.)

solubility

water: 642.6 g/L at 20 °C

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤50 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

storage temp.

room temp

SMILES string

[Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

InChI

1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1

InChI key

PPASLZSBLFJQEF-RXSVEWSESA-M

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General description

Sodium ascorbate, also known as mineral ascorbate, is the sodium salt of ascorbic acid, commonly referred to as vitamin C. This water-soluble molecule finds diverse applications, prominently in cell biology, where it serves as a crucial reducing agent to mitigate oxidative stress. Its significance extends to biochemical research, where it functions as an essential nutrient for both humans and animals. Additionally, sodium ascorbate acts as a cofactor for numerous enzymes involved in cellular metabolism, playing roles as an endogenous antioxidant, coenzyme, and metabolite in metabolomics studies.

In biochemical research, L-ascorbic acid sodium salt demonstrates its versatility as a collagen deposition enhancer and an elastogenesis inhibitor. These attributes contribute to its broader applications in understanding cellular processes and mechanisms, making it an indispensable tool for exploring various facets of biochemistry, metabolomics and cellular biology.
Vitamin C (ascorbic acid), a low-molecular-weight carbohydrate has an ene-diol structure. It is an abundant water-soluble electron donor in nature. Vitamin C is abundantly found in fruits and vegetables.

Application

(+)-Sodium L-ascorbate has been used:
  • as a standard to study the antioxidant and cytotoxicological effects of aloe vera food supplements
  • in the preparation of solution B for the detection of mitochondrial DNA replication using 5-ethynyl-2′-deoxyuridine (EdU)
  • to prepare EdU-labeling solution
  • to prepare β-galactosidase staining solution

Biochem/physiol Actions

Vitamin C (ascorbic acid) serves as a reductant. It plays a vital role in vascular function.

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.
Starting material for the synthesis of chiral building blocks; L-Ascorbic acid, review

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H. Omura and K. Yamafuji et al.
Antibiotics, Vitamins and Hormones, 115-115 (1977)
J.A.J.M. Vekemans et al.
Rec. Trav. Chim., 104, 266-266 (1987)
J.A. Vekemans et al.
The Journal of Organic Chemistry, 52, 1093-1093 (1987)
Transmembrane Ca2+ signaling and a new class of inhibitors.
H Hidaka et al.
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Martina Lepore Signorile et al.
Cell death & disease, 12(4), 316-316 (2021-03-27)
The prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene
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