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11039

Sigma-Aldrich

L-Arginine monohydrochloride

≥99.5% (AT), suitable for ligand binding assays, BioUltra

Synonym(s):

(S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2 · HCl
CAS Number:
Molecular Weight:
210.66
Beilstein:
3631658
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

product name

L-Arginine monohydrochloride, BioUltra, ≥99.5% (AT)

product line

BioUltra

Quality Level

Assay

≥99.5% (AT)

form

powder or crystals

optical activity

[α]20/D +22.0±0.5°, c = 5% in 5 M HCl

technique(s)

ligand binding assay: suitable

impurities

insoluble matter, passes filter test
≤0.3% foreign amino acids

ign. residue

≤0.05%

loss

≤0.05% loss on drying, 20 °C (HV)

color

colorless

pH

5.5-7.0 (25 °C, 1 M in H2O)

mp

220-230 °C

solubility

H2O: 1 M at 20 °C, clear, colorless

density

1.42 g/cm3 at 20 °C

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: ≤0.2
λ: 280 nm Amax: ≤0.1

SMILES string

Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O

InChI

1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1

InChI key

KWTQSFXGGICVPE-WCCKRBBISA-N

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Application

L-Arginine monohydrochloride has been used to study the reversal of the inhibitory effect of L-NG0-nitroarginine on non-cholinergic relaxations. It has also been used as a dietary supplement to study its effect on endothelium-dependent vasodilation.

Biochem/physiol Actions

L-Arginine is considered as a semi essential amino acid. In most mammals including humans, L-Arginine synthesis occurs through intestinal-renal axis, from glutamine, glutamate and proline. Abnormal levels of L-Arginine is associated with the development of kidney and cardiovascular disease. L-arginine is found to decrease fat mass and visceral adiposity.
Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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L-arginine for the treatment of centrally obese subjects: a pilot study.
Hurt RT
Journal of Dietary Supplements, 11(1), 40-52 (2014)
Antiatherogenic Effects of L-Arginine in the Hypercholesterolemic Rabbit
John P. Cooke
The Journal of Clinical Investigation, 90, 1168- 1172 (1992)
L-NG monomethyl arginine and L-NG-nitro arginine inhibit
non-adrenergic, non-cholinergic relaxation of the mouse
anococcygeus muscle
A. Gibson
British Journal of Pharmacology, 99, 602-606 (1990)
L-Arginine and its metabolites in kidney and cardiovascular disease.
Popolo A
Amino Acids, 46(10), 2271-2286 (2014)
Carolina Di Somma et al.
Endocrine, 49(2), 492-502 (2014-11-10)
The aim of the study is to clarify the relationship between adipose tissue dysfunction, metabolic profile and growth hormone (GH)/insulin-like growth factor (IGF)-I secretion in healthy adult subjects. We investigated the metabolic profile in a cohort of 231 consecutive healthy

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