Skip to Content

尊敬的客户:

目前国际形势复杂多变,关税政策尚不明朗,这可能对我们的产品价格产生一定影响。在此情况下,我们希望就订单事宜与您进行友好沟通。

基于当前的不确定性,如果您选择在此期间下单,我们将保留根据实际情况调整价格的权利。同时,我们也理解市场变化可能给您带来的困扰,因此如果在订单实际发货前因关税政策变动导致价格出现较大波动,默克将与您进行协商讨论并视情况对订单进行调整或取消。

关于应对近期政策变化的重要更新,请点击此处查看详情。

Merck
CN

108319

SAFC

TRIS hydrochloride

EMPROVE® EVOLVE

Pharma Manufacturing

Synonym(s):

Trizma® hydrochloride, TRIS HCl, TRIS hydrochloride, Tris(hydroxymethyl)aminomethane hydrochloride, Tromethane hydrochloride

Sign Into View Organizational & Contract Pricing

Select a Size

1 G
CN¥3,694.48

CN¥3,694.48


Please contact Customer Service for Availability

Request a Bulk OrderRequest a Sample

Select a Size

Change View
1 G
CN¥3,694.48

About This Item

Linear Formula:
NH2C(CH2OH)3 · HCl
CAS Number:
Molecular Weight:
157.60
Beilstein:
3675235
MDL number:
UNSPSC Code:
12161700

CN¥3,694.48


Please contact Customer Service for Availability

Request a Bulk OrderRequest a Sample

biological source

synthetic

Quality Level

description

Manufactured under appropriate controls for use as a raw material in BioProcessing

product line

EMPROVE® EVOLVE

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

Endotoxin, tested
Microbial, tested
Trace Metals, tested

useful pH range

7.0-9.0

pKa (25 °C)

8.1

suitability

suitable for manufacturing use

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
571155713157132
separation technique

normal phase

separation technique

normal phase

separation technique

normal phase

separation technique

normal phase

particle size

100-200 mesh

particle size

100-200 mesh

particle size

100-200 mesh

particle size

100-200 mesh

matrix

magnesium silicate base material

matrix

magnesium silicate base material

matrix

magnesium silicate base material

matrix

magnesium silicate base material

application(s)

food and beverages

application(s)

food and beverages

application(s)

food and beverages

application(s)

food and beverages

volume

6 mL

volume

12 mL

volume

20 mL

volume

60 mL

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

As part of our EMPROVE® Program, our raw materials are offered with EMPROVE® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Buffer quality is vital for the success of biopharmaceutical processes, because buffers are indispensable in nearly every production step.

Our broad portfolio of buffer materials manufactured under appropriate controls is tailored to your needs. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

Tris HCl is a commonly used biological buffer. Tris/Tris HCl as a buffering system has a very broad usage in biological systems for biopharmaceutical manufacturing, cell culture, diagnostics and molecular biology. The pKa of Tris is 7.77 which corresponds closely to a physiological pH of 7.36.

Tris HCl is used as the conjugate buffer component with Tris/Tromethamine/Trizma in biopharmaceutical buffer formulations (both upstream and downstream applications), electrophoresis separations and diagnostic reagent formulations.

Other Notes

The pH values of all buffers are temperature and concentration dependent. For Tris buffers, pH increases about 0.03 unit per °C decrease in temperature, and decreases 0.03-0.05 unit per ten-fold dilution. For precise applications, use a carefully calibrated pH meter with a glass/calomel combination electrode.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
Trizma is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


  • What is the Emprove® Program?

    The Emprove® Program is a system providing comprehensive and thorough documentation of our filters and single-use components, pharma raw materials, and starting materials. Four document types are included with an Emprove® Program subscription:

    Material Qualification Dossier

    Free of charge - Sign in to download

    Quality Management Dossier (Open Access)

    Free of charge - Sign in to download

    Quality Management Dossier (Open Access)

    Free of charge - Sign in to download

    Operational Excellence Dossier

    Available by subscription or for a fee

    Learn more about the benefits an Emprove® Program subscription can provide
    Why are these documents unavailable?
    Emprove® Dossiers contain information intended to support the registration process and risk assessment activities of pharmaceutical producers and contain confidential information. Please contact us if you would like access.

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Difficulty Finding Your Product Or Lot/Batch Number?

    Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

    Example:

    T1503
    Product Number
    -
    25G
    Pack Size/Quantity

    Additional examples:

    705578-5MG-PW

    PL860-CGA/SHF-1EA

    MMYOMAG-74K-13

    1000309185

    enter as 1.000309185)

    Having trouble? Feel free to contact Technical Service for assistance.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service