10817
Apolipoprotein A-I from human plasma
≥90% (GE)
Synonym(s):
Apo A-1
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About This Item
Form:
lyophilized solid
Assay:
≥90% (GE)
Biological source:
human plasma
biological source
human plasma
assay
≥90% (GE)
form
lyophilized solid
Gene Information
human ... APOA1(335)
solubility
H2O: 1 mg/mL, clear, colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
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General description
Apolipoprotein A-I (apoA-I) is the chief protein component of high density lipoproteins (HDL) and a major determinant of HDL structure, composition, and stability. It is an exchangeable apolipoprotein and plays pivotal role in the metabolism of cholesterol.
Application
Apolipoprotein A-I (apoA-I) was used for protecting the heart against vascular disease, it also protects other vascular beds and organs. It was protective against atherosclerosis through its ability to intervene in reverse cholesterol transport.
Biochem/physiol Actions
High-density lipoproteins are antiatherogenic and cardioprotective by facilitating reverse cholesterol transport (RCT). Some strategies for elevating apolipoprotein A-I levels are studied as therapies for atherosclerosis.
Preparation Note
lyophilized from 0.01 M ammonium hydrogen carbonate
Other Notes
A principal protein component of high-density lipoproteins. Protein - lipid interactions
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Weiling Wang et al.
Journal of lipid research, 51(9), 2560-2570 (2010-05-26)
The relationship between high-density lipoprotein and pulmonary function is unclear. To determine mechanistic relationships we investigated the effects of genetic deletion of apolipoprotein A-I (apoA-I) on plasma lipids, paraoxonase (PON1), pro-inflammatory HDL (p-HDL), vasodilatation, airway hyperresponsiveness and pulmonary oxidative stress
Jens O Lagerstedt et al.
Biochimica et biophysica acta, 1821(3), 448-455 (2012-01-17)
Apolipoprotein A-I (apoA-I) is the major protein component of high density lipoproteins (HDL) and plays a central role in cholesterol metabolism. The lipid-free/lipid-poor form of apoA-I is the preferred substrate for the ATP-binding cassette transporter A1 (ABCA1). The interaction of
R.B. Gennis et al.
Annual Review of Biophysics and Biophysical Chemistry, 6, 195-195 (1977)
Scott M Gordon et al.
Current opinion in endocrinology, diabetes, and obesity, 19(2), 109-114 (2012-01-27)
To review recently published advances in the development of apolipoprotein A-I (apoA-I) mimetic peptides as a potential treatment for cardiovascular diseases. Various apoA-I mimetic peptides are currently in development and these display potent cardioprotective features that can rival or even
Ryan J Henderson et al.
Lipids in health and disease, 8, 27-27 (2009-07-25)
Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of atherosclerosis which causes coronary artery disease, the
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