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Merck
CN

07602

FSB staining solution

1 % (w/v) in DMSO, fluorescent stain for amyloid

Synonym(s):

1-Fluoro-2,5-bis[(E)-3-carboxy-4-hydroxystyryl]benzene solution, 3,3′-[(2-Fluoro-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis[6-hydroxybenzoic acid] solution

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About This Item

Empirical Formula (Hill Notation):
C24H17FO6
CAS Number:
760988-03-2
Molecular Weight:
420.39
UNSPSC Code:
12352200
PubChem Substance ID:
329748488
NACRES:
NA.32

Key Documents

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SMILES string

OC(C1=CC(/C=C/C2=CC=C(/C=C/C3=CC(C(O)=O)=C(O)C=C3)C(F)=C2)=CC=C1O)=O

InChI

1S/C24H17FO6/c25-20-13-16(2-1-14-5-9-21(26)18(11-14)23(28)29)4-8-17(20)7-3-15-6-10-22(27)19(12-15)24(30)31/h1-13,26-27H,(H,28,29)(H,30,31)/b2-1+,7-3+

InChI key

DZXZHGCGNRRJEG-WMWQKROPSA-N

form

liquid

concentration

1 % (w/v) in DMSO

UV absorption

λ: 360-380 nm Amax: 0.6-0.9

storage temp.

2-8°C

General description

1-Fluoro-2,5-bis[(E)-3-carboxy-4-hydroxystyryl]benzene solution (FSB ) is an amyloid-β peptide (Aβ) specific dye. It is a fluorine analog of 1-Bromo-2,5-bis(3-carboxy-4-hydroxystyryl)benzene (BSB). It also acts as an amyloidophilic fluorescent probe for Aβ.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F

flash_point_c

87 °C

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3349
BCCD8812
BCCB8153
BCBW5166
BCBP8793V

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FK506 reduces amyloid plaque burden and induces MMP-9 in AβPP/PS1 double transgenic mice.
Hong H S, et al.
Journal of Alzheimer'S Disease, 22(1), 97-105 (2010)

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