03907
Tioconazole
97%
Synonym(s):
1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole
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About This Item
Empirical Formula (Hill Notation):
C16H13Cl3N2OS
CAS Number:
Molecular Weight:
387.71
PubChem Substance ID:
UNSPSC Code:
51302325
NACRES:
NA.85
EC Number:
265-973-8
MDL number:
Quality Level
assay
≥96.5% (HPLC), 96.5-103.5% (NT), 97%
form
powder
color
white to off-white
antibiotic activity spectrum
fungi, yeast
mode of action
cell membrane | interferes
SMILES string
Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1
InChI
1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2
InChI key
QXHHHPZILQDDPS-UHFFFAOYSA-N
General description
Chemical structure: pyrimidine
Application
Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.
Biochem/physiol Actions
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.
Packaging
10G
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
A L Fachin et al.
Medical mycology, 39(1), 129-133 (2001-03-29)
The electrophoretic pattern of the intracellular esterase of the dermatophyte Trichophyton rubrum was altered when this fungus was grown in the presence of subinhibitory concentrations of the antimycotics tioconazole or griseofulvin. All strains (original isolate and antimycotic resistant mutants) presented
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 49823-25MG | 04061832421742 |
| 03907-10G | 04061838628435 |