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Merck
CN

03907

Tioconazole

97%

Synonym(s):

1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole

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About This Item

Empirical Formula (Hill Notation):
C16H13Cl3N2OS
CAS Number:
65899-73-2
Molecular Weight:
387.71
PubChem Substance ID:
329747834
UNSPSC Code:
51302325
NACRES:
NA.85
EC Number:
265-973-8
MDL number:
MFCD00057276

Key Documents

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InChI

1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2

InChI key

QXHHHPZILQDDPS-UHFFFAOYSA-N

assay

≥96.5% (HPLC), 96.5-103.5% (NT), 97%

form

powder

color

white to off-white

antibiotic activity spectrum

fungi, yeast

mode of action

cell membrane | interferes

Quality Level

100

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General description

Chemical structure: pyrimidine

Application

Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.

Biochem/physiol Actions

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.

Packaging

10G

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7076
BCCK4244
BCCF3563
BCCC7546
BCBX4302

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M Pereira et al.
Mycopathologia, 143(2), 71-75 (1999-04-17)
Understanding the genetic mechanisms involved in resistance to antifungal agents is important in the fight against pathogenic fungi. In the present investigation we studied a strain of the model fungus Aspergillus nidulans which presents resistance to tioconazole and behaves as
J R Dean et al.
Journal of AOAC International, 80(1), 7-13 (1997-01-01)
Supercritical fluid extraction (SFE) followed by packed column supercritical fluid chromatography with ultraviolet detection was evaluated as a quantitative method for determining 4 antifungals (fluconazole, tioconazole, hexaconazole, and UK-47,265) in rodent diet. Chromatography was achieved with a cyano-bonded silica column
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
C Nolting et al.
Mycoses, 40 Suppl 1, 73-75 (1997-01-01)
We report on a 75 year old patient with a bronchial asthma treated at least for 15 years with low dose prednisolone. Under this treatment he developed a tinea follicularis and was demonstrated in our clinic with papulopustular skin lesions
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