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Merck
CN

A1010

Arsenic(III) oxide

ReagentPlus®, ≥99.0%

Synonym(s):

Arsenic trioxide, Arsenous acid

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About This Item

Empirical Formula (Hill Notation):
As2O3
CAS Number:
1327-53-3
Molecular Weight:
197.84
NACRES:
NA.55
PubChem Substance ID:
329770647
UNSPSC Code:
12171602
EC Number:
215-481-4
MDL number:
MFCD00003433
Assay:
≥99.0%
Form:
powder

Key Documents

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Product Name

Arsenic(III) oxide, ReagentPlus®, ≥99.0%

InChI key

IKWTVSLWAPBBKU-UHFFFAOYSA-N

InChI

1S/As2O3/c3-1-5-2-4

SMILES string

O=[As]O[As]=O

vapor pressure

0 hPa ( 66 °C)

product line

ReagentPlus®

assay

≥99.0%

form

powder

storage temp.

room temp

Quality Level

200

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Application

Arsenic(III) oxide was used in a study detailing the effect of arsenic trioxide in combination with γ-irradiation to elucidate the hemoglobin (Hb).

Biochem/physiol Actions

Very potent agent against acute promyelocytic leukemia (APL). Causes skin, lung and bladder cancer.

General description

Arsenic(III) oxide, also known as arsenic trioxide, is an amphoteric oxide that serves as a raw material for the synthesis of several arsenic-based compounds. It is utilized to decolorize glasses and enamels. Its efficacy in treating in acute promyelocytic leukaemia (APL) has been investigated.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

target_organs

Respiratory system,Cardio-vascular system,Gastrointestinal tract

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3474
BCCM5851
BCCJ8941
BCCG8449
BCCG0159

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should product A1010, Arsenic(III) oxide be dissolved?

    This product is soluble in 1 M NaOH  at 66 mg/ml, with heat as needed, yielding a clear, colorless solution.  This information can be found on the Product Information Sheet.

  6. What is the solution stablity of A1010, Arsenic(III) oxide?

    We do not have any solution stability data for product A1010. Thus it is best to make up fresh solutions of A1010.

  7. What is the difference between Product Nos. A1010 and 202673, Arsenic(III) oxide?

    Both products are Arsenic(III) oxide.  The specifications for the products differ. Please see the Specification Sheets for details.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Combined effect of arsenic trioxide and radiation on physical properties of hemoglobin biopolymer.
Saad-El-Din AA, et al.
Journal of Radiation Research and Applied Sciences, 7(2), 411-416 (2014)
Wilson H Miller et al.
Cancer research, 62(14), 3893-3903 (2002-07-19)
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsed patients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations
E Lengfelder et al.
Leukemia, 26(3), 433-442 (2011-09-10)
Arsenic trioxide (ATO) is presently the most active single agent in the treatment of acute promyelocytic leukemia (APL). This review provides insights into the mode of action and the pharmacological properties of ATO, and summarizes the most relevant results of
Dikshith TSS
Handbook of Chemicals and Safety, 92-92 (1992)
Z X Shen et al.
Blood, 89(9), 3354-3360 (1997-05-01)
The therapeutic effect of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) was evaluated among 15 APL patients at relapse after all-trans retinoic acid (ATRA) induced and chemotherapy maintained complete remission (CR). As2O3 was administered intravenously at
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Product Information Sheet - A1010

Product Information Sheet

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