91707
Trifluoroacetic acid
puriss. p.a., suitable for HPLC, ≥99.0% (GC)
Synonym(s):
TFA
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About This Item
Linear Formula:
CF3COOH
CAS Number:
Molecular Weight:
114.02
Beilstein:
742035
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.21
Recommended Products
vapor density
3.9 (vs air)
vapor pressure
97.5 mmHg ( 20 °C)
grade
puriss. p.a.
Assay
≥99.0% (GC)
form
liquid
technique(s)
HPLC: suitable
LC/MS: suitable
impurities
≤0.05% water
refractive index
n20/D 1.3 (lit.)
pH
1 (20 °C, 1 g/L)
bp
72.4 °C (lit.)
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General description
Trifluoroacetic acid (TFA) is a fluorinated acetic acid. It is widely used as trifluoromethylating reagent for trifluoromethylation of aromatic compounds.
Application
Trifluoroacetic acid (TFA) may be used in the following studies:
- Preparation of TFA reagent for the estimation of serum vitamin A.
- To compose the binary solvent system for the isolation of large denatured peptides by reverse phase high performance liquid chromatography.
- A mobile-phase additive for liquid chromatography-mass spectrometry (LC-MS) analysis.
- Preparation of artemisinin under optimized reaction conditions.
Packaging
package with 10x1mL
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 2
Flash Point(F)
>212.0 °F - Pensky-Martens closed cup
Flash Point(C)
> 100 °C - Pensky-Martens closed cup
Regulatory Information
危险化学品
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Continuous-flow synthesis of the anti-malaria drug artemisinin.
François Lévesque et al.
Angewandte Chemie (International ed. in English), 51(7), 1706-1709 (2012-01-18)
Guangfa Shi et al.
Organic letters, 17(1), 38-41 (2014-12-18)
Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in
W C Mahoney et al.
The Journal of biological chemistry, 255(23), 11199-11203 (1980-12-10)
A method employing reverse phase high performance liquid chromatography has been developed for the purification of large denatured peptides. The cyanogen bromide fragments of hemoglobin alpha, beta, and gamma chains (13 to 91 residues in length) could be separated and
Macro- and micromethods for the determination of serum vitamin A using trifluoroacetic acid.
J B Neeld et al.
The Journal of nutrition, 79, 454-462 (1963-04-01)
Risto Kostiainen et al.
Journal of chromatography. A, 1216(4), 685-699 (2008-09-19)
The most widely used ionization techniques in liquid chromatography-mass spectrometry (LC-MS) are electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI). All three provide user friendly coupling of LC to MS. Achieving optimal LC-MS conditions is
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