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676853

Sigma-Aldrich

Dichloromethane

ACS reagent, ≥99.5%, contains 40-150 ppm amylene as stabilizer

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Synonym(s):
Methylene chloride
Empirical Formula (Hill Notation):
CH2Cl2
CAS Number:
Molecular Weight:
84.93
Beilstein:
1730800
EC Number:
MDL number:
UNSPSC Code:
12352101
PubChem Substance ID:
NACRES:
NA.04

grade

ACS reagent

Quality Level

vapor density

2.9 (vs air)

vapor pressure

24.45 psi ( 55 °C)
6.83 psi ( 20 °C)

Assay

≥99.5%

form

liquid

autoignition temp.

1223 °F

contains

40-150 ppm amylene as stabilizer

expl. lim.

22 %

impurities

Free halogens, passes test
≤0.0003 meq/g Titr. acid
≤0.02% water

evapn. residue

≤0.002%

color

APHA: ≤10

refractive index

n20/D 1.424 (lit.)

bp

39.8-40 °C (lit.)

mp

−95 °C (lit.)

density

1.325 g/mL at 25 °C (lit.)

SMILES string

ClCCl

InChI

1S/CH2Cl2/c2-1-3/h1H2

InChI key

YMWUJEATGCHHMB-UHFFFAOYSA-N

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Related Categories

Application


  • Synthesis of Remdesivir Derivate as a Generation of Anti-COVID-19 Drugs Through Acetylation Reactions.: This study involves the synthesis of a derivative of Remdesivir, aiming to enhance anti-COVID-19 activity through acetylation. Dichloromethane plays a critical role in the solvent system used during synthesis, impacting the reaction conditions and outcomes (Sumardi et al., 2023).

  • Antioxidant potentials of extracts from different parts of Clinacanthus nutans (Burm. f.) Lindau.: Investigates the antioxidant properties of various extracts from Clinacanthus nutans, where dichloromethane is utilized for the extraction process. This research highlights dichloromethane′s efficiency in isolating antioxidant compounds from plant materials (Duy Dang K et al., 2024).

  • Correlation between intestinal toxicity and composition changes of toxic parts from Euphorbia ebracteolata before and after Terminalia chebula soup processing: Discusses changes in toxic components of Euphorbia ebracteolata post-processing. Dichloromethane is critical for extracting and analyzing these components, demonstrating its importance in toxicological assessments (Lin WH et al., 2024).

  • Isolation of a Marker Olean-12-en-28-butanol Derivative from Viscum continuum E. Mey. Ex Sprague and the Evaluation of Its Antioxidant and Antimicrobial Potentials.: Focuses on isolating specific compounds from Viscum continuum using dichloromethane, illustrating its utility in pharmacognosy for identifying bioactive substances (Mapfumari et al., 2024).

Features and Benefits

ACS solvents meet or exceed the high standards of the American Chemical Society (ACS) ,with test specifications that are specialized to every compound. According to the American Chemical Society, ACS reagent grade implies that it is a substance of sufficient purity to be used in most chemical analyses or reactions.

Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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Matthew J Walters et al.
Nature protocols, 2(7), 1825-1830 (2007-07-21)
A procedure for the preparation of optically pure alpha-keto-gamma-hydroxy carboxylic acids through stereospecific aldol addition catalyzed by pyruvate aldolases from the Entner-Doudoroff and the DeLey-Doudoroff glycolytic pathways is described. This highly versatile fragment serves as a precursor for a variety
Dichloromethane Detection Based on Near-Infrared Absorptive Sensing.
Han JH and Yoon SM
IEEE Journal of Selected Topics in Quantum Electronics, 18(5), 1547-1552 (2012)
Vitamin B12-mediated hydrodechlorination of dichloromethane by bimetallic Cu/Al particles.
Huang CC, et al.
Chemical Engineering Journal, 273, 413-420 (2015)
Biodegradation of dichloromethane in an estuarine environment.
Krausova VI, et al.
Hydrobiologia, 559(1), 77-83 (2006)
Rodney C Baker et al.
Methods in enzymology, 538, 89-105 (2014-02-18)
Mass spectrometry technology has enabled significant advances in detailing the alterations of the lipidome in response to pathological conditions or experimental manipulations. Lipids comprise a wide range of compounds with functions that include structural, intracellular signaling, trafficking, and storage. Characterization

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