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55460

Sigma-Aldrich

Hydroxylamine hydrochloride

puriss. p.a., ACS reagent, ≥99.0% (RT)

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Synonym(s):
Hydroxylammonium chloride
Linear Formula:
NH2OH · HCl
CAS Number:
5470-11-1
Molecular Weight:
69.49
Beilstein:
3539763
EC Number:
226-798-2
MDL number:
MFCD00051089
UNSPSC Code:
12352300
PubChem Substance ID:
329758115
NACRES:
NB.24

grade

ACS reagent
puriss. p.a.

Quality Level

300

vapor pressure

0.001 hPa ( 50 °C)

Assay

≥99.0% (RT)

form

powder or crystals

technique(s)

inhibition assay: suitable

ign. residue

≤0.05% (as SO4)

pH

2.5-3.5 (25 °C, 50 mg/mL in H2O)

mp

155-157 °C (dec.) (lit.)

density

1.67 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg
heavy metals: ≤5 ppm (by ICP)

SMILES string

Cl.NO

InChI

1S/ClH.H3NO/c;1-2/h1H;2H,1H2

InChI key

WTDHULULXKLSOZ-UHFFFAOYSA-N

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General description

Hydroxylamine hydrochloride (Hydroxylammonium chloride) is the hydrochloride salt of hydroxylamine. It participates in the synthesis of 1,2,4-oxadiazoles.

Application



  • Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs.: This study utilized hydroxylamine hydrochloride in mass spectrometry to analyze the extracellular matrix proteins in various mouse organs, offering insights into tissue-specific protein compositions (McCabe et al., 2023).


  • Analysis of extracellular metabolome by HS-SPME/GC-MS: Optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity.: Hydroxylamine hydrochloride was employed in HS-SPME/GC-MS to optimize the analysis of extracellular metabolites, crucial for assessing hepatotoxic effects (Araújo et al., 2018).


  • Improved production and processing of ⁸⁹Zr using a solution target.: This research enhanced the production process of zirconium-89 with hydroxylamine hydrochloride, improving efficiency and yield for medical imaging applications (Pandey et al., 2016).


  • Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery.: The study used hydroxylamine hydrochloride to modify gold nanoparticles, improving their biocompatibility and effectiveness in siRNA delivery systems (Rahme et al., 2015).


  • Preparation and photocatalytic performance of Fe (III)-amidoximated PAN fiber complex for oxidative degradation of azo dye under visible light irradiation.: Hydroxylamine hydrochloride was used in the synthesis of Fe(III)-amidoximated PAN fibers, enhancing their photocatalytic degradation properties for environmental applications (Dong et al., 2010).


Biochem/physiol Actions

MAO inhibitor; inhibits platelet aggregation.

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Target Organs

spleen

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Selective dissolution of manganese oxides from soils and sediments with acidified hydroxylamine hydrochloride.
Chao TT.
Soil Science Society of America Journal. Soil Science Society of America, 36(5), 764-768 (1972)
Transamidation of primary amides with amines using hydroxylamine hydrochloride as an inorganic catalyst.
C Liana Allen et al.
Angewandte Chemie (International ed. in English), 51(6), 1383-1386 (2012-01-04)
Satu Hänninen et al.
Bio-protocol, 7(9), e2268-e2268 (2017-05-05)
Glycerophospholipids consist of a glycerophosphate backbone to which are esterified two acyl chains and a polar head group. The head group (e.g., choline, ethanolamine, serine or inositol) defines the glycerophospholipid class, while the acyl chains together with the head group
Magnesia-supported hydroxylamine hydrochloride in the presence of sodium carbonate as an efficient reagent for the synthesis of 1, 2, 4-oxadiazoles from nitriles.
Kaboudin B and Saadati F.
Tetrahedron Letters, 48(16), 2829-2832 (2007)
Bereket Y Oquare et al.
Bioconjugate chemistry, 19(11), 2196-2204 (2008-10-04)
We report the design and synthesis of an orthogonally protected peptide nucleic acid (PNA) building block, Fmoc-PNA-U'-(Dde)-OH, and its use in the construction of PNA FRET probes. This building block allows for the post-synthetic attachment of reporter groups to the
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