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375810

Sigma-Aldrich

Periodic acid

ACS reagent, 99%

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Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
EC Number:
233-937-0
MDL number:
MFCD00011344
UNSPSC Code:
12352106
PubChem Substance ID:
329755660
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

Assay

99%
99.0-101.0% (ACS specification)

form

powder or crystals

reaction suitability

reaction type: C-H Activation
reagent type: catalyst
reagent type: oxidant

impurities

≤0.01% insolubles
≤0.01% other halogens

ign. residue

≤0.01%

mp

122 °C (lit.)

solubility

water: soluble

anion traces

sulfate (SO42-): ≤0.01%

cation traces

Fe: ≤0.003%
heavy metals: ≤0.005%

application(s)

histology

SMILES string

OI(O)(O)(O)(O)=O

InChI

1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)

InChI key

TWLXDPFBEPBAQB-UHFFFAOYSA-N

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General description

Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid. Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiff′s reagent. Therefore periodic-acid-Schiff′s reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.

Application

Periodic acid may be used in the following reactions:
  • Oxidation of alcohols to ketones and aldehydes.
  • Oxidation hydroxylamine derivatives.
  • Oxidation of arenes to quinones.
  • Deprotection of the dithio- and oxathio-derivatives.
  • Oxidative degradation of epoxidized natural rubber (ENR).
  • Oxidation of urazoles and bis-urazoles to triazolinediones.
  • Oxidative cleavage of glucosazone.

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

Target Organs

Thyroid

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

危险化学品

Certificates of Analysis (COA)

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Periodic Acid Oxidation.
Jackson EL.
Organic Reactions, 341-375 null
Carbohydrate histochemistry studied by acetylation techniques: I. Periodic acid methods.
McManus JFA and Cason JE.
The Journal of Experimental Medicine, 91(6), 651-651 (1950)
Histological and histochemical uses of periodic acid.
J F A McMANUS
Stain technology, 23(3), 99-108 (1948-07-01)
Chemical degradation of epoxidized natural rubber using periodic acid: Preparation of epoxidized liquid natural rubber.
Phinyocheep P, et al.
Journal of Applied Polymer Science, 95(1), 6-15 (2005)
Further Observations Concerning the Periodic Acid Oxidation of Hydroxylamine Derivatives1.
Emery TF and. Neilands JB.
The Journal of Organic Chemistry, 27(3), 1075-1077 (1962)
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