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375810

Sigma-Aldrich

Periodic acid

ACS reagent, 99%

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25 G
CN¥839.76
100 G
CN¥2,270.62

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25 G
CN¥839.76
100 G
CN¥2,270.62

About This Item

Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
EC Number:
233-937-0
MDL number:
MFCD00011344
UNSPSC Code:
12352106
PubChem Substance ID:
329755660
NACRES:
NA.21

CN¥839.76

Available to ship onApril 10, 2025Details

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grade

ACS reagent

Assay

99%
99.0-101.0% (ACS specification)

form

powder or crystals

reaction suitability

reaction type: C-H Activation
reagent type: catalyst
reagent type: oxidant

impurities

≤0.01% insolubles
≤0.01% other halogens

ign. residue

≤0.01%

mp

122 °C (lit.)

solubility

water: soluble

anion traces

sulfate (SO42-): ≤0.01%

cation traces

Fe: ≤0.003%
heavy metals: ≤0.005%

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This Item
379891P787577310
Periodic acid ACS reagent, 99%

375810

Periodic acid

Periodic acid 99.999% trace metals basis

379891

Periodic acid

Periodic acid ReagentPlus®, ≥99.0%

P7875

Periodic acid

Periodic acid puriss. p.a., ACS reagent, crystallized, ≥99.0% (RT)

77310

Periodic acid

assay

99%, 99.0-101.0% (ACS specification)

assay

99.999% trace metals basis

assay

≥99.0%

assay

≥99.0% (RT)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

form

powder or crystals

form

crystals

form

powder or crystals

form

powder or crystals

solubility

water: soluble

solubility

water: soluble

solubility

water: 100 mg/mL, clear, colorless

solubility

water: soluble

mp

122 °C (lit.)

mp

122 °C (lit.)

mp

122 °C (lit.)

mp

122 °C (lit.)

General description

Periodic acid is an inorganic acid commonly used as an oxidizing agent. Periodic acid oxidation[1] is one of the steps in the periodate-resorcinol assay, used in the determination of sialic acid.[2] Periodic acid reacts with 1,2 glycol linkage of carbohydrates to form aldehydes which can be stained by Schiff′s reagent. Therefore periodic-acid-Schiff′s reagent (PAS) is used in histochemistry to determine carbohydrates in tissue sections.[3][4]

Application

Periodic acid may be used in the following reactions:
  • Oxidation of alcohols to ketones and aldehydes.[5][6]
  • Oxidation hydroxylamine derivatives.[7]
  • Oxidation of arenes to quinones.[8]
  • Deprotection of the dithio- and oxathio-derivatives.[9]
  • Oxidative degradation of epoxidized natural rubber (ENR).[10]
  • Oxidation of urazoles and bis-urazoles to triazolinediones.[11]
  • Oxidative cleavage of glucosazone.[12]

Signal Word

Danger

Hazard Statements

H271,H314,H372,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral

Target Organs

Thyroid

Storage Class Code

5.1A - Strongly oxidizing hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

危险化学品
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCL2653
    BCCK7597
    BCCG6110
    BCCF1091
    BCBS6452V

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    Deblocking of dithioacetals and oxathioacetals using periodic acid under mild nonaqueous conditions.
    Shi XX, et al.
    Tetrahedron Letters, 37(25), 4331-4334 (1996)
    The Action of Periodic Acid on Glucose Phenylosazone.
    Chargaff E and Magasanik B.
    Journal of the American Chemical Society, 69(6), 1459-1461 (1947)
    The sialic acids. XI. A periodate-resorcinol method for the quantitative estimation of free sialic acids and their glycosides.
    G W Jourdian et al.
    The Journal of biological chemistry, 246(2), 430-435 (1971-01-25)
    The first report on the catalytic oxidation of urazoles to their corresponding triazolinediones via in situ catalytic generation of Br+ using periodic acid or oxone/KBr system.
    Zolfigol MA, et al.
    J. Mol. Catal. A: Chem., 270(1), 219-224 (2007)
    Pyridinium chlorochromate catalyzed oxidation of alcohols to aldehydes and ketones with periodic acid.
    Hunsen M.
    Tetrahedron Letters, 46(10), 1651-1653 (2005)
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