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34874

Sigma-Aldrich

1,1,2-Trichloro-1,2,2-trifluoroethane

suitable for HPLC, ≥99.7% (GC)

Synonym(s):

1,1,2-Trichloro-trifluoroethane, Genetron® 113

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About This Item

Linear Formula:
ClCF2CCl2F
CAS Number:
76-13-1
Molecular Weight:
187.38
Beilstein:
1740335
EC Number:
200-936-1
MDL number:
MFCD00000782
UNSPSC Code:
41116105
PubChem Substance ID:
329755081

vapor pressure

5.5 psi ( 20 °C)

Assay

≥99.7% (GC)

autoignition temp.

1256 °F

technique(s)

HPLC: suitable

impurities

≤0.0005% non-volatile matter
≤0.001% free acid (as CH3COOH)
≤0.005% water (Karl Fischer)

transmittance

235 nm, ≥20%
245 nm, ≥80%
260 nm, ≥98%

refractive index

n20/D 1.358 (lit.)

bp

47-48 °C (lit.)

mp

−35 °C (lit.)

density

1.57 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

FC(F)(Cl)C(F)(Cl)Cl

InChI

1S/C2Cl3F3/c3-1(4,6)2(5,7)8

InChI key

AJDIZQLSFPQPEY-UHFFFAOYSA-N

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General description

1,1,2-Trichloro-1,2,2-trifluoroethane is a chlorofluorocarbon solvent. It affords C2H2F2 and CH4, via Pd/TiO2 catalyzed-reaction with hydrogen at 420-820K. Chlorotrifluoroethene is formed as the main reaction product during the electrodechlorination of 1,1,2-trichloro-1,2,2-trifluoroethane (CFC 113) in the presence of palladium (catalyst).

Application

1,1,2-Trichloro-1,2,2-trifluoroethane may be used for purifying the insulin-like growth factor-I (IGF-I) isolated from the serum of wild western gray kangaroos.

Other Notes

Sales restrictions may apply

Legal Information

Genetron is a registered trademark of Honeywell International Inc.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H319,H411,H420

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Ozone 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

383.0 °F

Flash Point(C)

195 °C

Regulatory Information

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C A Yandell et al.
The Journal of endocrinology, 156(1), 195-204 (1998-03-13)
Insulin-like growth factor-I (IGF-I) and IGF-II have been purified to homogeneity from kangaroo (Macropus fuliginosus) serum, thus this represents the first report of the purification, sequencing and characterisation of marsupial IGFs. N-Terminal protein sequencing reveals that there are six amino
Palladium-Assisted Electrodehalogenation of 1, 1, 2-Trichloro-1, 2, 2-trifluoroethane on Lead Cathodes Combined with Hydrogen Diffusion Anodes.
Cabot PL, et al.
Journal of the Electrochemical Society, 144(11), 3749-3757 (1997)
Coadsorption of organic compounds and water vapor on BPL activated carbon. 2. 1, 1, 2-Trichloro-1, 2, 2-trifluoroethane and dichloromethane.
Eissmann RN and Le Van MD.
Industrial & Engineering Chemistry Research, 32(11), 2752-2757 (1993)
Conversion of 1, 1, 2-trichloro-1, 2, 2-trifluoroethane (CFC113) over TiO2-supported metal and metal oxide catalysts.
Takita Y, et al.
Chemistry Letters (Jpn), 5, 715-718 (1990)
Y Michael et al.
International journal of pharmaceutics, 221(1-2), 165-174 (2001-06-09)
The nature of the drug-drug aggregation phenomena between salmeterol xinafoate and fluticasone propionate used in a metered-dose inhaler system has been examined. Interactions between the drugs in the solvents 1,1,2-trichlorotrifloroethane (CFC-113) and 1,1,1,2-tetrafluoroethane (HFA-134a) have been characterised using a focused
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