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Safety Information

345547

Sigma-Aldrich

Hydrogen chloride solution

4.0 M in dioxane

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About This Item

Empirical Formula (Hill Notation):
HCl
CAS Number:
7647-01-0
Molecular Weight:
36.46
MDL number:
MFCD00011324
UNSPSC Code:
12352301
PubChem Substance ID:
329755029
NACRES:
NA.21
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form

liquid

Quality Level

200

concentration

3.80-4.40 M (by NaOH, titration)
4.0 M in dioxane

density

1.05 g/mL at 25 °C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

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Show Differences

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This Item
OGS621OGS620OGS619
pSF-CMV-NEO-NH2-PPT-FLAG plasmid vector for molecular cloning

OGS624

pSF-CMV-NEO-NH2-PPT-FLAG

pSF-CMV-NH2-PPT-3XFLAG plasmid vector for molecular cloning

OGS621

pSF-CMV-NH2-PPT-3XFLAG

pSF-CMV-NH2-3XFLAG plasmid vector for molecular cloning

OGS620

pSF-CMV-NH2-3XFLAG

pSF-CMV-COOH-FLAG plasmid vector for molecular cloning

OGS619

pSF-CMV-COOH-FLAG

peptide cleavage

EKT

peptide cleavage

EKT

peptide cleavage

EKT

peptide cleavage

EKT

origin of replication

pUC

origin of replication

pUC

origin of replication

pUC

origin of replication

pUC

peptide tag location

N-terminal

peptide tag location

N-terminal

peptide tag location

N-terminal

peptide tag location

C-terminal

bacteria selection

ampicillin

bacteria selection

ampicillin

bacteria selection

ampicillin

bacteria selection

ampicillin

mol wt

size 5913 bp

mol wt

size 4610 bp

mol wt

size 4568 bp

mol wt

size 4530 bp

General description

Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides. [1]

Application

Hydrogen chloride solution (4.0 M in dioxane) can be used as:     
  • A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.[2]     
  • A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.[3]      
  • A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).[4]

Signal Word

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

62.6 °F - closed cup

Flash Point(C)

17 °C - closed cup

Regulatory Information

监管及禁止进口产品

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCX1684
    MKCW7333
    BCCL4933
    MKCV8291
    MKCW3205

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m)
    G H, et al.
    The Journal of Peptide Research, 4, 338-341 (2001)
    Synthesis of Chitosan-graft-Poly (vinyl ether) as a Thermoresponsive Water-Soluble Chitosan
    Namikoshi T, et al.
    Journal of Fiber Science and Technology, 75(12), 193-199 (2019)
    Preparation of N-9-fluorenylmethoxycarbonylamino acid chlorides from mixed anhydrides by the action of hydrogen chloride 1
    FRANCIS C MF, et al.
    International Journal of Peptide and Protein Research, 38, 97-102 (1991)
    Yun He et al.
    Bioorganic & medicinal chemistry letters, 13(19), 3253-3256 (2003-09-03)
    A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent
    Surface-and redox-active multifunctional polyphenol-derived poly (ionic liquid) s: controlled synthesis and characterization
    Patil N, et al.
    Macromolecules, 49(20), 7676-7691 (2016)
    View All Related Papers

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