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27109

Sigma-Aldrich

Citric acid

meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance)

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2
CAS Number:
77-92-9
Molecular Weight:
192.12
Beilstein:
782061
EC Number:
201-069-1
MDL number:
MFCD00011669
UNSPSC Code:
12352106
eCl@ss:
39021801
PubChem Substance ID:
329752978
NACRES:
NA.21

Quality Level

200

Assay

99.5-100.5% (based on anhydrous substance)

form

grit

quality

anhydrous
meets analytical specification of Ph. Eur., BP, USP, E330

expl. lim.

8 %, 65 °F

impurities

residual solvents, complies
≤0.0005% heavy metals (as Pb)
≤0.5% water (Karl Fischer)

ign. residue

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

mp

153-159 °C (lit.)

solubility

water: 383 g/L at 25 °C

anion traces

chloride (Cl-): ≤50 ppm
oxalate (as oxalic acid): ≤100 ppm
sulfate (SO42-): ≤100 ppm

cation traces

As: ≤1 ppm
Ca: ≤200 ppm
Cu: ≤10 ppm
Fe: ≤10 ppm
Hg: ≤1 ppm
Pb: ≤0.5 ppm
Zn: ≤10 ppm

suitability

complies for appearance of solution
complies for reaction against H2SO4

SMILES string

OC(=O)CC(O)(CC(O)=O)C(O)=O

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChI key

KRKNYBCHXYNGOX-UHFFFAOYSA-N

Gene Information

human ... SRC(6714)

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Application

Citric acid was used as a test reagent for studying whether the novel pyridazinylpiperazine analog TPRV-1 inhibitor can reduce cough reflex induced by citric acid and capsaicin in guinea pig.

Biochem/physiol Actions

Citric acid in dietary form can augments absorption of aluminium in antacids. It also facilitates the phytoremediation of heavy metal contaminated soil and can transform cadmium into more transportable forms.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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P Slanina et al.
Clinical chemistry, 32(3), 539-541 (1986-03-01)
Ten healthy men ingested, twice daily between meals, during each of the seven-day experimental periods: (a) citric acid (as lemon juice), (b) Al(OH)3, or (c) Al(OH)3 + citric acid. Whole blood sampled after each dietary period was analyzed electrothermally after
Y X Chen et al.
Chemosphere, 50(6), 807-811 (2003-04-12)
Adsorption and hydroponics experiments were conducted to study the role of citric acid on the phytoremediation of heavy metal contaminated soil. The results show that addition of citric acid decreased the adsorption of both lead and cadmium, such an effect
Sum Yee Leung et al.
Cough (London, England), 3, 10-10 (2007-12-25)
Cough reflex can be induced by the pepper extract capsaicin and by low pH in guinea-pig airways. Transient receptor potential vanniloid-1 (TPRV-1) is expressed in the sensory and afferent nerve fibres in airways. We hypothesized that a novel pyridazinylpiperazine analog
Konrad Hoetzenecker et al.
European heart journal, 36(11), 676-685 (2013-01-17)
Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia. Inflammatory dilated cardiomyopathy (iDCM) is a common cause of heart failure in young patients.
Tetsuji Sawada et al.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 18(1), 119-128 (2014-02-04)
The G-Project committee was erected by the Japan Society for Gastroenterological Carcinogenesis with an aim of establishing a new classification scheme based on molecular biological characteristics that would supplement the conventional TNM classification to better predict outcome. In a literature
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